In the area of computational imaging, his focus is on integrative computational imaging systems for biomedical imaging (inventor/co-inventor of Correlated Diffusion Imaging, Compensated Magnetic Resonance Imaging, Spectral Light-field Fusion Micro-tomography, Compensated Ultrasound Imaging, Coded Hemodynamic Imaging, High-throughput Computational Slits, Spectral Demultiplexing Imaging, and Parallel Epi-Spectropolarimetric Imaging). In the area of artificial intelligence, his focus is on operational artificial intelligence (co-inventor/inventor of , Generative Synthesis, evolutionary deep intelligence, Deep Bayesian Residual Transform, Discovery Radiomics, and random deep intelligence via deep-structured fully-connected graphical models). His work in Generative Synthesis has led to the founding of DarwinAI, a leading-edge AI company focused on accelerated deep learning development.