My research involves the application of brain mapping techniques to brain tumor patients. We use multiple functional brain mapping techniques (functional MRI and intracranial EEG) to better understand the brain basis of behavior. The goals are: 1) to use these techniques to define individual functional anatomy in patients with brain tumors, 2) to cross validate information acquired through different techniques and to gain a better understanding of the relationship between these different brain signals, 3) to demonstrate the ways in which the functional anatomy is altered by disease and recovery, and 4) to use this information to improve surgical therapy for patients with brain tumors. In order to accomplish this, our program includes the following: 1) direct cortical electrophysiologic recording and analysis techniques; 2) advanced functional MR (fMRI) imaging; 3) research methods including data analysis, interpretation, and presentation; and 4) the theoretical underpinnings and investigative tools of current cognitive neuroscience. We perform multi-modality studies of memory-associated cognitive processes in healthy people and patients with brain tumors. This research benefits from numerous collaborators from radiology, engineering, HMS, Brandeis, and MIT.