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This was among the first demonstration of enzyme induction in mammals. This work, along with his subsequent research at the National Institutes of Health (Bethesda, MD) illustrated how chemicals could induce the enzymes that catalyze the metabolism of many other compounds. In the 1960s and 1970s, working at Burroughs Wellcome & Co. Inc. and then at Hoffmann-La Roche Inc., Dr. Conney investigated the metabolism of many drugs by cytochrome P450 and other enzymes. Further characterization of numerous factors that regulate drug-metabolizing enzymes by Dr. Conney and his colleagues led to the discovery of multiple forms of cytochrome P450 enzymes. This enzyme system metabolizes a variety of drugs, steroid hormones, carcinogens, and other environmental chemicals. His work provided the molecular basis for our understanding of how drugs, other xenobiotics, and endogenous compounds are biotransformed and how these processes can be influenced by different environmental chemicals, including those present in the diet. Dr. Conney's seminal research has greatly impacted the fields of pharmacology, toxicology, and oncology.
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ANTICANCER RESEARCHno. 7 (2014): 3357.0-3363.0
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Asian Pacific Journal of Cancer Preventionno. 21 (2014): 9341-9346
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