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Streitwieser was one of the pioneers of molecular orbital theory and his book Molecular Orbital Theory for Organic Chemists had a lasting impact on the field.He is also well-known for proposing the currently accepted interpretation of the origin of secondary deuterium kinetic isotope effects. Streitwieser developed the technique of using protium/deuterium exchange to measure the acidity of exceedingly weak carbon acids and was a codeveloper of the MSAD acidity scale, named for the first initials of the chemists who developed it.His Chemical Reviews article titled "Solvolytic Displacement Reactions at Saturated Carbon" was influential in the field of physical organic chemistry. Streitwieser is also the author of the widely used university textbook Introduction to Organic Chemistry (4th revised ed., 1998, with Heathcock and Kosower, ISBN 0139738509, German translation, Organische Chemie, ISBN 3527258108), as well as the autobiography A Lifetime of Synergy With Theory and Experiment (ISBN 0841218366)
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FOUNDATIONS OF PHYSICAL ORGANIC CHEMISTRY: FIFTY YEARS OF THE JAMES FLACK NORRIS AWARD (2015): 77-92
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