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Dr. Tidball’s research has centered around utilizing human induced pluripotent stem cells to study neurological diseases. His current research focus is to understand the mechanisms of malformations of human brain development, including anencephaly, hemimegaloencephaly, and focal cortical dysplasia. Dozens of potentially causative de novo mutations (DNMs) have recently been identified for each of these conditions due to advances in sequencing technology. His research seeks to provide evidence for the causality of these genetic variants and understanding for the mechanisms by which they cause brain malformations. He is also interested in the mechanisms of neuro-teratogens, compounds that disrupt development of the central nervous system when ingested by the mother. For all of these studies, he employs human induced pluripotent stem cells and brain organoids combined with CRISPR gene-editing and transcriptional interference.
研究兴趣
论文共 25 篇作者统计合作学者相似作者
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Taylor N Takla,Jinghui Luo,Roksolana Sudyk, Joy Huang, J Clayton Walker,Neeta L Vora,Jonathan Z Sexton,Jack M Parent,Andrew M Tidball
bioRxiv : the preprint server for biology (2023)
Andrew M. Tidball, Luis F. Lopez-Santiago,Yukun Yuan,Trevor W. Glenn, Joshua L. Margolis, J. Clayton Walker, Emma G. Kilbane,Lori L. Isom,Jack M Parent
biorxiv(2020)
Andrew M Tidball, Luis F Lopez-Santiago,Yukun Yuan,Trevor W Glenn, Joshua L Margolis, J Clayton Walker, Emma G Kilbane,Christopher A Miller,E Martina Bebin,M Scott Perry,Lori L Isom,Jack M Parent
CELLULAR AND ANIMAL MODELS IN HUMAN GENOMICS RESEARCH (2019)
Terry Jo V Bichell,Michal Wegrzynowicz,K Grace Tipps,Emma M Bradley,Michael A Uhouse,Miles Bryan,Kyle Horning,Nicole Fisher,Karrie Dudek, Timothy Halbesma, Preethi Umashanker, Andrew D Stubbs,
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