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Much of Anna Mapp's research focuses upon developing a molecular-level picture of inducible gene expression in eukaryotes using organic molecules as mechanistic probes. Regulated gene expression is critical for cellular existence, and a number of human diseases such as cancer and diabetes have been linked to aberrant patterns of gene expression. Therefore, a goal of primary importance in the scientific community is the discovery of transcription-based therapeutics capable of reprogramming gene expression in diseased cells while leaving normal cells unaffected. While a general sequence of events that leads to gene up-regulation is agreed upon, the molecular-level interactions that regulate the levels and time course of transcriptional activation remain unknown. A more detailed picture of gene regulation is a prerequisite for the eventual development of transcription-based therapeutics.
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论文共 180 篇作者统计合作学者相似作者
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Journal of Biological Chemistryno. 3 (2024)
Olivia N. Pattelli,Estefania Martinez Valdivia,Matthew S. Beyersdorf, Clint S. Regan,Monica Rivas, Katherine A. Hebert,Sofia D. Merajver,Tomasz Cierpicki,Anna K. Mapp
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2024)
Olivia N Pattelli,Estefanía Martínez Valdivia,Matthew S Beyersdorf, Clint S Regan,Mónica Rivas, Katherine A Hebert,Sofia D Merajver,Tomasz Cierpicki,Anna K Mapp
Angewandte Chemie (International ed. in English)pp.e202400781-e202400781, (2024)
Chemical scienceno. 43 (2023): 12068-12072
bioRxiv : the preprint server for biology (2023)
Amanda L Peiffer, Julie M Garlick,Yujin Wu,Jesse W Wotring, Sahil Arora, Alexander S Harmata,Daniel A Bochar,Corey J Stephenson,Matthew B Soellner,Jonathan Z Sexton,Charles L Brooks,Anna K Mapp
ACS medicinal chemistry lettersno. 6 (2023): 860-866
Meghan E Breen,Stephen T Joy, Omari J Baruti,Matthew S Beyersdorf, Madeleine J Henley,Samantha N De Salle, Peter D Ycas,Ayza Croskey,Tomasz Cierpicki,William C K Pomerantz,Anna K Mapp
Chembiochem : a European journal of chemical biologyno. 21 (2023): e202300439-e202300439
bioRxiv : the preprint server for biology (2023)
Yejun Liu,Stephen T. Joy, Madeleine J. Henley,Ayza Croskey,Joel A. Yates,Sofia D. Merajver,Anna K. Mapp
Biochemistryno. 1 (2023): 1-8
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