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Since almost thirty years Dr. Arcangeli is being involved in studies aimed at defining the biophysical aspects of intracellular signalling controlling cell growth and differentiation of tumor cells. She contributed to unravel the action mechanism of widely used inducers of tumor cell differentiation, such as the "hybrid polar compounds" (HPC). She also focused on the role of potassium channels, in particular the hERG1 channel, in the govern of the resting potential, cellular ionic homeostasis and cell signalling in normal and cancer cells. In this field, Dr. Arcangeli acquired most of the methodologies required to accomplish the present proposal, in particular gene manipulation, biomolecular techniques and patch clamping. Meanwhile, in the last few years she exploited her skill in mouse transgenesis and in vivo experiments in immunodeficient mice. These studies led to discovery that, in many human and experimental tumors, the resting potential is controlled by hERG1, an important family of recently discovered potassium channels. Moreover, Dr. Arcangeli integrating biophysical, biomolecular and genetic approaches unravelled the role of potassium channels and their encoding genes, in embryonic development and tumor establishment.
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Expert opinion on therapeutic targetspp.1-13, (2024)
Claudia Duranti,Jessica Iorio,Giacomo Bagni,Ginevra Chioccioli Altadonna, Thibault Fillion,Matteo Lulli, Franco Nicolas D'Alessandro,Alberto Montalbano,Elena Lastraioli,Duccio Fanelli,Stefano Coppola,Thomas Schmidt,
Life science allianceno. 1 (2023): e202302135-e202302135
G. Lori,M. Pastore,N. Navari, B. Piombanti, R. Booijink, E. Rovida, I. Tusa, M. Lewinska,J. B. Andersen, T. Lottini,A. Arcangeli,M. L. Taddei,
Digestive and Liver Disease (2023): S225-S226
Molecular cancer therapeuticsno. 3 (2023): 343-356
Data in Brief (2023): 109343-109343
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Elena Lastraioli, Alessandra Bettiol,Jessica Iorio, Elvira Limatola, Daniele Checcacci, Erica Parisi, Cristina Bianchi,Annarosa Arcangeli, Mauro Iannopollo,Francesco Di Costanzo, Marco Di Lieto
Cellsno. 11 (2023): 1458-1458
European journal of medicinal chemistry (2023): 115561-115561
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