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个人简介
Anne O’Garra studies the control of immune responses effected by cell–cell interactions and proteins known as cytokines. Anne first discovered that the cytokine interleukin-10 suppresses antigen presentation and limits production of inflammation-promoting cytokines by the immune system’s dendritic cells and macrophages. She discovered that dendritic cells produce interleukin-12, which mobilises T cells to fight intracellular pathogens. Although the balance between suppression by interleukin-10 and production of pro-inflammatory cytokines is critical for preventing host damage, it can also lead to chronic infection.
Using a transcriptomic approach Anne recently uncovered pathways underlying the immune response in tuberculosis, revealing mechanisms of pathogenesis and potential approaches for improved diagnosis and treatment monitoring. Consequently, Anne’s work has the potential to open up new preventative and therapeutic treatments for inflammatory and infectious diseases, including tuberculosis.
In addition to being a Fellow of the Royal Society, Anne was also elected a Fellow of the Academy of Medical Sciences, a Fellow of the American Association for the Advancement of Science and as a Member of EMBO, the European Molecular Biology Organization.
研究兴趣
论文共 240 篇作者统计合作学者相似作者
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Marisol Alvarez-Martinez, Luke S Cox,Claire F Pearson,William J Branchett,Probir Chakravarty,Xuemei Wu, Hubert Slawinski,Alaa Al-Dibouni, Vasileios A Samelis,Leona Gabryšová,Simon L Priestnall, Alejandro Suárez-Bonnet,
Nature immunologypp.1-16, (2024)
Wellcome open research (2023): 403-403
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Marisol Alvarez-Martinez,Luke S. Cox,Claire F. Pearson,William J. Branchett,Probir Chakravarty,Xuemei Wu, Hubert Slawinski,Alaa Al-Dibouni, Vasileios A. Samelis,Leona Gabryšová,Simon L. Priestnall,Alejandro Suárez-Bonnet,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Wellcome Open Research (2023)
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Simon Rousseau, Matoula Papoutsopoulou,Antony Symons, Dorthe Cook,John M. Lucocq,Alan R. Prescott,Anne O'Garra,Steven C. Ley,Philip Cohen
Journal of Cell Scienceno. 21 (2022)
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