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In pioneering work, the Bassett group is identifying and characterizing genetic subtypes of schizophrenia. It is now apparent that a substantial proportion of patients with schizophrenia may have a new or inherited genetic change involving one of several major copy number variants. These structural genetic changes represent an important genetic mechanism in schizophrenia that may also have congenital and later onset medical conditions as part of their expression. The associated genomic disorders present opportunities for research findings to be directly translated into clinical practice. 22q11.2 Deletion Syndrome (22q11.2DS) is the prototype of these multisystem disorders. The associated 22q11.2 deletion is the first and most powerful molecular risk factor identified for schizophrenia. Animal (e.g., mouse) models are available and can confirm and extend human research discoveries, including those related to physical illness, cognitive functioning, brain imaging, neuropathology and treatment response.
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Genetics in Medicineno. 5 (2024): 101088-101088
HUMAN BRAIN MAPPINGno. 1 (2024): e26553-e26553
medRxiv (Cold Spring Harbor Laboratory) (2024): 101145
Ali AlMail,Ahmed Jamjoom,Amy Pan, Min Yi Feng,Vann Chau, Alissa M D'Gama,Katherine Howell, Nicole S Y Liang,Amy McTague,Annapurna Poduri,Kimberly Wiltrout, IPCHiP Executive Committee,
Ruben Gur,Carrie Bearden,Sébastien Jacquemont, Khadije Jizi, Therese Amelsvoort van,Marianne van den Bree,Jacob Vorstman,Jonathan Sebat,Kosha Ruparel, Robert Gallagher,Ann Swillen,Emily McClellan,
Research square (2023)
Marlene Rong,Tim Benke,Quratulain Zulfiqar Ali,Ángel Aledo-Serrano,Allan Bayat,Alessandra Rossi,Orrin Devinsky,Farah Qaiser, Anum S Ali,Alfonso Fasano,Anne S Bassett, Danielle M Andrade
Neurology. Geneticsno. 6 (2023): e200105-e200105
Genetics in Medicine Openno. 1 (2023): 100141
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