Our lab has implemented phage-based protein display systems in connection with computational and bioinformatics methodologies harnessing the power of rapidly expanding computing capabilities and high throughput experimental technologies for antibody/protein engineering and antibody/protein design. The research directions are aiming at innovating antibody/protein design and engineering technologies and understanding the biological function of natural antibody repertoires with synthetic phage-displayed antibody libraries and bioinformatics; the goal is to develop antibody-based molecules for important biomedical applications.