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职业迁徙
个人简介
My research focuses on how cells communicate with one another and the underlying molecular signalling pathways. In particular, how the levels of the intracellular messenger, Ca2+, are controlled by extracellular stimuli in both time and space.
Ca2+ signalling is implicated in myriad cellular events, from fast processes such as neurotransmission to slow processes such as gene expression. When Ca2+ signalling goes wrong, disease ensues. Moreover, Ca2+ signalling pathways can be subverted by infectious agents to their own ends. Therefore, drugs that affect Ca2+ signals may therefore correct diseases or reduce infection.
My current work examines the regulation of Ca2+ release from intracellular Ca2+-storing organelles – mainly endo-lysosomes and the endoplasmic reticulum (ER) – via the second messengers NAADP and IP3. I focus on the bidirectional cross-talk between these two organelles using a combination of molecular biology and single-cell fluorescence microscopy.
Ca2+ signalling is implicated in myriad cellular events, from fast processes such as neurotransmission to slow processes such as gene expression. When Ca2+ signalling goes wrong, disease ensues. Moreover, Ca2+ signalling pathways can be subverted by infectious agents to their own ends. Therefore, drugs that affect Ca2+ signals may therefore correct diseases or reduce infection.
My current work examines the regulation of Ca2+ release from intracellular Ca2+-storing organelles – mainly endo-lysosomes and the endoplasmic reticulum (ER) – via the second messengers NAADP and IP3. I focus on the bidirectional cross-talk between these two organelles using a combination of molecular biology and single-cell fluorescence microscopy.
研究兴趣
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Cell Calcium (2023): 102801-102801
Cell Calcium (2023): 102815-102815
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2023)
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Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2021)
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2021)
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