Arjan Kortholt

Department of Molecular Cell Biology, University of Groningen, Kerklaan 30, 9751NN Haren, The Netherlands

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Allosteric modulation of the GTPase activity of a bacterial LRRK2 homologue by conformation-specific Nanobodies

Margaux Leemans, Christian Galicia,Egon Deyaert, Elise Daems, Linda Krause, Jone Paesmans, Els Pardon,Jan Steyaert,Arjan Kortholt, Frank Sobott, Dagmar Klostermeier, Wim Versées

The Biochemical journal, no. 7 (2020): 1203-1218

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Roco Proteins : GTPases with a Baroque Structure and Mechanism

Lina Wauters,Wim Versées,Arjan Kortholt

International Journal of Molecular Sciences, no. 1 (2019): 147

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Structure and nucleotide-induced conformational dynamics of the Chlorobium tepidum Roco protein

Egon Deyaert, Margaux Leemans,Ranjan Kumar Singh,Rodrigo Gallardo,Jan Steyaert,Arjan Kortholt,Janelle Lauer,Wim Versées

The Biochemical journal, (2018)

Cited by2WOSBibtex

Structure and nucleotide-induced conformational dynamics of the Roco protein

Egon Deyaert, Margaux Leemans,Ranjan Kumar Singh,Rodrigo Gallardo,Jan Steyaert,Arjan Kortholt,Janelle Lauer, Wim Versées

Biochemical Journal, (2018)

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The role of (auto)-phosphorylation in the complex activation mechanism of LRRK2

Panagiotis S. Athanasopoulos,Rolf Heumann,Arjan Kortholt

BIOLOGICAL CHEMISTRY, no. 7 (2018): 643-647

Cited by2Bibtex

Structure and nucleotide-induced conformational dynamics of theChlorobium tepidumRoco protein

Egon Deyaert, Margaux Leemans,Ranjan Kumar Singh,Rodrigo Gallardo,Jan Steyaert,Arjan Kortholt,Janelle Lauer,Wim Versées

Biochemical Journal, no. 1 (2018): 51-66

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Coupled excitable Ras and F-actin activation mediates spontaneous pseudopod formation and directed cell movement

Peter J M van Haastert,Ineke Keizer-Gunnink,Arjan Kortholt

Molecular biology of the cell, no. 7 (2017): 922-934

Cited by17WOSBibtex

The LRR-Roc-COR module of the Chlorobium tepidum Roco protein: crystallization and X-ray crystallographic analysis

Egon Deyaert,Arjan Kortholt,Wim Versées

Acta crystallographica. Section F, Structural biology communications, no. Pt 9 (2017): 520-524

Cited by2WOSBibtex

Role of the small GTPase Rap1 in signal transduction, cell dynamics and bacterial infection

Hubert Hilbi,Arjan Kortholt

Small GTPases, pp.1-7, (2017)

Cited by5WOSBibtex

GPCR-controlled membrane recruitment of negative regulator C2GAP1 locally inhibits Ras signaling for adaptation and long-range chemotaxis

Xuehua Xu, Xi Wen,Douwe M. Veltman,Ineke Keizer-Gunnink, Henderikus Pots,Arjan Kortholt,Tian Jin

Proceedings of the National Academy of Sciences of the United States of America, no. 47 (2017): E10092-E10101

Cited by4WOSBibtex

A homologue of the Parkinson's disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover

Egon Deyaert, Lina Wauters,Giambattista Guaitoli,Albert Konijnenberg, Margaux Leemans,Susanne Terheyden,Arsen Petrovic,Rodrigo Gallardo, Laura M Nederveen-Schippers, Panagiotis S Athanasopoulos, Henderikus Pots,Peter J M Van Haastert

Nature communications, no. 1 (2017): 1008-1008

Cited by30WOSBibtex

Structural model of the dimeric Parkinson’s protein LRRK2 reveals a compact architecture involving distant interdomain contacts

Giambattista Guaitoli, Francesco Raimondi, Francesco Raimondi,Bernd K. Gilsbach,Bernd K. Gilsbach,Yacob Gómez-Llorente,Egon Deyaert, Fabiana Renzi,Xianting Li, Adam Schaffner,Pravin Kumar Ankush Jagtap,Karsten Boldt

Proceedings of the National Academy of Sciences of the United States of America, no. 30 (2016): 201523708

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The unconventional G-protein cycle of LRRK2 and Roco proteins

Susanne Terheyden, Laura M Nederveen-Schippers,Arjan Kortholt

BIOCHEMICAL SOCIETY TRANSACTIONS, no. 6 (2016): 1611-1616

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Connecting G protein signaling to chemoattractant-mediated cell polarity and cytoskeletal reorganization

Youtao Liu,Jesus Lacal,Richard A Firtel,Arjan Kortholt

Small GTPases, pp.1-5, (2016)

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Direct Interaction between TalinB and Rap1 is necessary for adhesion of Dictyostelium cells

Katarzyna Plak, Henderikus Pots,Peter J M Van Haastert,Arjan Kortholt

BMC Cell Biology, no. 1 (2016): 1-1

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Activation Mechanism of LRRK2 and Its Cellular Functions in Parkinson’s Disease

Katharina E. Rosenbusch,Arjan Kortholt

Parkinson's Disease, (2016): 7351985-7351985

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Conformational heterogeneity of the Roc domains in C. tepidum Roc-COR and implications for human LRRK2 Parkinson mutations

Katharina Rudi,Franz Y Ho,Bernd Gilsbach, Henderikus Pots,Alfred Wittinghofer,Arjan Kortholt,Johann P Klare

BIOSCIENCE REPORTS, (2015)

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Abstract B48: Homer3 regulates the establishment of neutrophil polarity

Julie Wu,Anne Pipathsouk,A. Keizer-Gunnink, Wynand Alkema,Fabrizia Fusetti,Shanshan Liu, Steve Atschuler,Lani F. Wu,Arjan Kortholt,Orion D. Weiner

Cancer immunology research, (2015)

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The Potential of Targeting LRRK2 in Parkinson’s Disease

Franz Y Ho, K E Rosenbusch,Arjan Kortholt

(2014)

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Dictyostelium Ric8 is a nonreceptor guanine exchange factor for heterotrimeric G proteins and is important for development and chemotaxis

Rama Kataria,Xuehua Xu,Fabrizia Fusetti,Ineke Keizer-Gunnink,Tian Jin,Peter J M van Haastert,Arjan Kortholt

Proceedings of the National Academy of Sciences of the United States of America, no. 16 (2013): 6424-6429

Cited by19WOSBibtex

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Papers31 papers

Arjan Kortholt