Arlene Sharpe

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Bio

Her laboratory has discovered and elucidated functions of T cell costimulatory pathways, including immunoinhibitory functions of the CTLA-4 and PD-1 pathways, that has laid the foundation for immune checkpoint blockade therapy in cancer. Her laboratory investigates roles of T cell costimulatory pathways in regulating T cell tolerance, antimicrobial and antitumor immunity, and translating this understanding into therapies for autoimmune diseases and cancer.

Research Interests

Papers共 674 篇Author StatisticsCo-AuthorSimilar Experts

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Figure S1 from PD-1 Expression on Intratumoral Regulatory T Cells is Associated with Lack of Benefit from Anti–PD-1 Therapy in Metastatic Clear-Cell Renal Cell Carcinoma Patients

Thomas Denize,Opeyemi A. Jegede,Sayed Matar,Nourhan El Ahmar,Destiny J. West,Emily Walton, Aseman Sheshdeh Bagheri, Varunika Savla, Yasmin Nabil Laimon,Saurabh Gupta, Sai Vikram Vemula,David A. Braun,Kelly P. Burke,Paul J. Catalano,Gordon J. Freeman,Robert J. Motzer,Michael B. Atkins,David F. McDermott,Arlene H. Sharpe,Toni K. Choueiri,Sabina Signoretti

openalex（2024）

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X-CHIME Enables Combinatorial, Inducible, Lineage-Specific and Sequential Knockout of Genes in the Immune System

Martin W. LaFleur, Ashlyn M. Lemmen, Ivy S. L. Streeter,Thao H. Nguyen,Lauren E. Milling, Nicole M. Derosia, Zachary M. Hoffman,Jacob E. Gillis, Qin Tjokrosurjo,Samuel C. Markson,Amy Y. Huang,Praju V. Anekal,Paula Montero Llopis,W. Nicholas Haining,John G. Doench,Arlene H. Sharpe

Nature Immunologyno. 1 (2024): 178-188

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Abstract 6592: Deciphering the Effects of Age on T Cell Immunity and Immunotherapy

SeongJun Han,Peter Georgiev,Jaime Schneider,Amy Huang, Zhanel Nugmanova,Thao H. Nguyen,Conghui Yao,Sheila Johnson,Shakchhi Joshi, Ishita Dhiman,Jefte M. Drijvers,Megan Fung,Jared H. Rowe,Brian C. Miller,Gordon J. Freeman,Alison E. Ringel,Marcia C. Haigis,Arlene H. Sharpe

Cancer Researchno. 6_Supplement (2024): 6592-6592

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Epigenetic Tuning of PD-1 Expression Improves Exhausted T Cell Function and Viral Control

Sarah A Weiss, Amy Y Huang,Megan E Fung, Daniela Martinez, Alex C Y Chen,Thomas J LaSalle,Brian C Miller,Christopher D Scharer, Mudra Hegde, Thao H Nguyen,Jared H Rowe, Jossef F Osborn,Dillon G Patterson, Natalia Sifnugel, C Mei-An Nolan, Richard A Davidson,Marc A Schwartz, Alexander P R Bally,Dennis K Neeld,Martin W LaFleur,Jeremy M Boss,John G Doench,W Nicholas Haining,Arlene H Sharpe,Debattama R Sen

Nature immunologyno. 10 (2024): 1871-1883

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Supplementary Tables 1-6 from PD-1 Expression on Intratumoral Regulatory T Cells is Associated with Lack of Benefit from Anti–PD-1 Therapy in Metastatic Clear-Cell Renal Cell Carcinoma Patients

Thomas Denize,Opeyemi Jegede,Sayed Matar, Nourhan El Ahmar,Destiny J. West,Emily Walton, Aseman Sheshdeh Bagheri, Varunika Savla, Yasmin Nabil Laimon,Saurabh Gupta,Sai Vikram Vemula,David A. Braun,Kelly P. Burke,Paul J. Catalano,Gordon J. Freeman,Robert J. Motzer,Michael B. Atkins,David F. McDermott,Arlene H. Sharpe,Toni K. Choueiri,Sabina Signoretti

openalex（2024）

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The B7:CD28 Family and Friends: Unraveling Coinhibitory Interactions

Kelly P. Burke,Apoorvi Chaudhri,Gordon J. Freeman,Arlene H. Sharpe

IMMUNITYno. 2 (2024): 223-244

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Framework for in Vivo T Cell Screens

Lauren E. Milling,Samuel C. Markson, Qin Tjokrosurjo, Nicole M. Derosia, Ivy S. L. Streeter, Grant H. Hickok, Ashlyn M. Lemmen,Thao H. Nguyen, Priyamvada Prathima,William Fithian,Marc A. Schwartz,Nir Hacohen,John G. Doench,Martin W. Lafleur,Arlene H. Sharpe

Journal of Experimental Medicine（2024）

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LAG-3 Sustains TOX Expression and Regulates the CD94/NKG2-Qa-1b Axis to Govern Exhausted CD8 T Cell NK Receptor Expression and Cytotoxicity

Shin Foong Ngiow,Sasikanth Manne, Yinghui Jane Huang, Tarek Azar,Zeyu Chen,Divij Mathew,Qingzhou Chen,Omar Khan,Jennifer E. Wu,Victor Alcalde,Ahron J. Flowers, Sean McClain,Amy E. Baxter,Makoto Kurachi,Junwei Shi, Alexander C. Huang,Josephine R. Giles,Arlene H. Sharpe,Dario A. A. Vignali,E. John Wherry

CELLno. 16 (2024)

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The Threshold Pattern of Calcineurin-Dependent Gene Expression is Altered by Loss of the Endogenous Inhibitor Calcipressin

Sandra Ryeom,Rebecca J Greenwald,Arlene H Sharpe,Frank McKeon

Nature immunology（2024）

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In Vivo CRISPR Screening Reveals CHD7 As a Positive Regulator of Short-lived Effector Cells

Martin W LaFleur, Jasmin M D'Andrea,Dillon G Patterson, Ivy S L Streeter, Matthew A Coxe, Jossef F Osborn,Lauren E Milling, Qin Tjokrosurjo, Jacob E Gillis, Thao H Nguyen,Marc A Schwartz,Nir Hacohen,John G Doench,Arlene H Sharpe

Journal of immunology (Baltimore, Md 1950) (2024)

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Papers共 674 篇Author StatisticsCo-AuthorSimilar Experts