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The optimization of stem cell transplantation therapy is considered one of the most important advances in the clinical management of childhood leukemia. The role of thermochemotherapy on the treatment of refractory or recurrent abdominal and pelvic tumors has been evaluated in a clinical research project funded by the German Cancer Aid, and thermochemotherapy has now been integrated as a complimentary part of multimodal therapy. Currently, the research also focuses on the development of tumor vaccines and immune modulatory drugs that shall induce a specific immune response.
Furthermore, research groups of the Clinic of Pediatric Oncology analyze genetic aberrations in childhood leukemia and cancer, in particular in pediatric germ cell tumors. This research aims on identifying genetic patterns that correlate with clinical course and outcome and can therefore be utilized for treatment stratification.
Several working groups are focussing on gene therapeutic approaches to childhood cancer and inherited hematologic disorders such as Fanconi Anemia. Here, the somatic gene transfer into hematopoietic stem cells as well as the transfer of suicide genes into tumor cells are under evaluation.
In close cooperation with national and international centers, the therapy guidelines for children and adolescents with immunodeficiency or rheumatoid disorders are optimized.
The optimization of stem cell transplantation therapy is considered one of the most important advances in the clinical management of childhood leukemia. The role of thermochemotherapy on the treatment of refractory or recurrent abdominal and pelvic tumors has been evaluated in a clinical research project funded by the German Cancer Aid, and thermochemotherapy has now been integrated as a complimentary part of multimodal therapy. Currently, the research also focuses on the development of tumor vaccines and immune modulatory drugs that shall induce a specific immune response.
Furthermore, research groups of the Clinic of Pediatric Oncology analyze genetic aberrations in childhood leukemia and cancer, in particular in pediatric germ cell tumors. This research aims on identifying genetic patterns that correlate with clinical course and outcome and can therefore be utilized for treatment stratification.
Several working groups are focussing on gene therapeutic approaches to childhood cancer and inherited hematologic disorders such as Fanconi Anemia. Here, the somatic gene transfer into hematopoietic stem cells as well as the transfer of suicide genes into tumor cells are under evaluation.
In close cooperation with national and international centers, the therapy guidelines for children and adolescents with immunodeficiency or rheumatoid disorders are optimized.
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Maik Tretbar, Julian Schliehe-Diecks, Lukas von Bredow, Kathrin Tan,Martin Roatsch,Jia-Wey Tu, Marie Kemkes,Melf Sönnichsen, Andrea Schöler,Arndt Borkhardt,Sanil Bhatia,Finn Kristian Hansen
crossref(2024)
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The Journal of clinical investigation (2024)
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BRITISH JOURNAL OF HAEMATOLOGYno. 2 (2024): 595-605
Wei Liu,Arndt Borkhardt,Dieter Häussinger,Aleksandra A Pandyra,Philipp A Lang,Haifeng Xu,Daniel Picard,Marc Remke,Pawel Stachura, Agnes Wlodarczyk, Olivia Stencel,Piyush Pandey,
Journal for ImmunoTherapy of Cancerno. Suppl 2 (2023)
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Rigveda Bhave, Ersen Kameri,Lutz Körschgen, Vera Jepsen, Katharina Hecker,Aleksandra A. Pandyra,Arndt Borkhardt,Ute Fischer,Gesine Koegler
Stem Cells Translational Medicineno. Supplement_1 (2023): S26-S26
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HemaSphereno. S3 (2023): e76470de-e76470de
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