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个人简介
RESEARCH INTERESTS
My interests are defined into lines of research:
Line of research #1 – Host:parasite:microbiota interactions
T. vaginalis is a mucosal extracellular parasite, which should interact with the surrounding microbiome. While most research elsewhere has traditionally considered host:trichomonad in isolation, the main differential aspect of my research is the consideration that trichomonad:microbiome interactions are also very influential to the outcomes of this infection and disease. This line of research started when establishing my independent laboratory in New Zealand (2011). Over these years, my group has shown that T. vaginalis and different vaginal bacteria display intimate interactions that change the behavior of each other in relation to the host. We have described host-protective effects of lactobacilli against T. vaginalis, and discovered specific factors involved in this protection. On the other hand, we have found that some vaginal dysbiotic bacteria interact metabolically with the parasite and enhance pathogenesis. We have also found that T. vaginalis has evolved with specific enzymes that may be capable of shaping the microbiome, giving the parasite an unforeseen advantage for infection. We think that this is a powerful model to understand pathogen:microbiome interactions in humans, and will lead to innovative ways for intervention and therapeutics.
Line of research #2 - The cellular and molecular biology of Trichomonas vaginalis.
As a Molecular Parasitologist with a strong training on molecular genetics, my research in this field has been biased to understand the basic processes of gene expression and regulation in this organism. In addition of being a medically important eukaryotic microorganism, T. vaginalis is also of relevance to understand the origins and evolution of eukaryotic life. My research has led to a series of discoveries towards improving our understanding on the conservation and divergence of these molecular processes in this protist as compared to model eukaryotes. This line of research was dominant during my postdoctoral training in the USA (2004-10), and since then carried over some of this to my own laboratory in New Zealand. This research has been seminal to advance our knowledge on the genome of this organism as well as the development of genetic tools including CRISPR-Cas9.
研究兴趣
论文共 44 篇作者统计合作学者相似作者
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Augusto Simoes-Barbosa, Jully Pinheiro
International Journal for Parasitology (2024)
Michael J Barnett, Jully Pinheiro,Jeremy R Keown,Jacob Biboy,Joe Gray, Ioana-Wilhelmina Lucinescu,Waldemar Vollmer,Robert P Hirt,Augusto Simoes-Barbosa,David C Goldstone
Molecular microbiology (2023)
Molecular Microbiology (2023)
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Marina Ferrari de Aquino,Augusto Simoes-Barbosa
Lifecycles of Pathogenic Protists in HumansMicrobiology Monographspp.541-617, (2022)
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