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Imhof Group
The structure of chromatin is critical for many aspects of cellular physiology and is considered to be the primary medium to store epigenetic information. It is defined by the histone molecules that constitute the nucleosome, the positioning of the nucleosomes along the DNA and the non-histone proteins that associate with it. All these factors help to establish and maintain a largely DNA sequence independent but surprisingly stable structure. The Imhof group studies the proteomic composition of distinct chromatin domains, the mechanisms that operate to maintain the composition of histone modifications and the associated proteins at a given DNA locus. We are interested in the effect of the concentration of key metabolites on the activity of enzymes that establish a specific chromatin structure and investigate how the modification patterns of changes upon physiological challenges such as memory formation or ageing. We also investigate the presence of chromatin proteins in human samples like to investigate their potential to serve as biomarkers for various pathological states.
The structure of chromatin is critical for many aspects of cellular physiology and is considered to be the primary medium to store epigenetic information. It is defined by the histone molecules that constitute the nucleosome, the positioning of the nucleosomes along the DNA and the non-histone proteins that associate with it. All these factors help to establish and maintain a largely DNA sequence independent but surprisingly stable structure. The Imhof group studies the proteomic composition of distinct chromatin domains, the mechanisms that operate to maintain the composition of histone modifications and the associated proteins at a given DNA locus. We are interested in the effect of the concentration of key metabolites on the activity of enzymes that establish a specific chromatin structure and investigate how the modification patterns of changes upon physiological challenges such as memory formation or ageing. We also investigate the presence of chromatin proteins in human samples like to investigate their potential to serve as biomarkers for various pathological states.
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Anna E Kiss, Anuroop V Venkatasubramani, Dilan Pathirana, Silke Krause,Aline Campos Sparr, Jan Hasenauer,Axel Imhof, Marisa Müller,Peter B Becker
Nucleic acids research (2024)
Cell Reportsno. 5 (2024): 114063-114063
PEDIATRIC NEPHROLOGYno. 1 (2024): 203-212
Giulia Giacomini,Sandra Piquet,Odile Chevallier,Juliette Dabin, Siau-Kun Bai,Byungjin Kim,Robert Siddaway,Brian Raught,Etienne Coyaud,Chun-Min Shan,Robert J. D. Reid, Takenori Toda,
Bastian Popper, Martina Bürkle, Giuliana Ciccopiedi,Marta Marchioretto,Ignasi Forné,Axel Imhof,Tobias Straub,Gabriella Viero,Magdalena Götz,Rico Schieweck
The Journal of biological chemistryno. 2 (2024): 105648-105648
Nature Communicationsno. 1 (2024): 1-20
Pediatric nephrology (Berlin, Germany)no. 1 (2024): 203-212
Matias Vinacour, Mauro Moiana,Ignasi Forne,Kirsten Jung, Micaela Bertea, Patricia M. Calero Valdayo,Pablo I. Nikel,Axel Imhof,Miranda C. Palumbo,Dario Fernandez Do Porto,Jimena A. Ruiz
APPLIED AND ENVIRONMENTAL MICROBIOLOGYno. 12 (2023): e0063023-e0063023
Cell metabolismno. 5 (2023): 821-+
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