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个人简介
The research of the Department of Molecular Biology is focussed on the molecular analysis of cellular signal transduction mechanisms and their significance for normal biological processes and pathophysiological phenomena such as cancer.
Disturbances in the communication between cells have gatal consequences: All cancer types and many other human diseases develop because the cellular signal transduction process is disturbed. Axel Ullrich and his team in the Research Department “Molecular Biology” are investigating the communication system by which information is transmitted from the cell surface into the cell ́s interior. The researchers want to understand how gene defects result in diseases in order to develop targeted drugs.
For cells to proliferate and form differentiated tissue – for example blood vessels, nerve tissue or connective tissue – they must be stimulated by so-called growth factors. These proteins bind to specific receptors on the cell surface and thus initiate a complex messaging cascade. Important components of this communication system are specific enzymes, the receptor tyrosine kinases (RTKs). They act as switches which can be activated by growth factors and thereby activate signaling pathways to the cell nucleus and other cell compartments.
Disturbances in the communication between cells have gatal consequences: All cancer types and many other human diseases develop because the cellular signal transduction process is disturbed. Axel Ullrich and his team in the Research Department “Molecular Biology” are investigating the communication system by which information is transmitted from the cell surface into the cell ́s interior. The researchers want to understand how gene defects result in diseases in order to develop targeted drugs.
For cells to proliferate and form differentiated tissue – for example blood vessels, nerve tissue or connective tissue – they must be stimulated by so-called growth factors. These proteins bind to specific receptors on the cell surface and thus initiate a complex messaging cascade. Important components of this communication system are specific enzymes, the receptor tyrosine kinases (RTKs). They act as switches which can be activated by growth factors and thereby activate signaling pathways to the cell nucleus and other cell compartments.
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论文共 481 篇作者统计合作学者相似作者
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Jens E. Ruhe,Sylvia Streit,Stefan Hart,Chee-Hong Wong,Katja Specht,Pjotr Knyazev,Tatjana Knyazeva, Liang Seah Tay,Hooi Linn Loo, Priscilla Foo, Winnie Wong,Sharon Pok,
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Jens E. Ruhe,Sylvia Streit, Stefan Hart,Chee-Hong Wong,Katja Specht,Pjotr Knyazev,Tatjana Knyazeva, Liang Seah Tay, Hooi Linn Loo, Priscilla Foo,Winnie Wong,Sharon Pok,
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Yi-Xiang Zhang, Peter G. Knyazev,Yuri V. Cheburkin,Kirti Sharma, Yuri P. Knyazev,László Őrfi,István Szabadkai, Henrik Daub,György Kéri,Axel Ullrich
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Yi-Xiang Zhang, Peter G. Knyazev,Yuri V. Cheburkin,Kirti Sharma, Yuri P. Knyazev,László Őrfi,István Szabadkai, Henrik Daub,György Kéri,Axel Ullrich
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Klaus Godl,Oliver J. Gruss, Jan Eickhoff,Josef Wissing, Stephanie Blencke, Martina Weber, Heidrun Degen,Dirk Brehmer,László Őrfi,Zoltán Horváth,György Kéri,Stefan Müller,
crossref(2023)
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Jens E. Ruhe,Sylvia Streit, Stefan Hart,Chee-Hong Wong,Katja Specht,Pjotr Knyazev,Tatjana Knyazeva, Liang Seah Tay, Hooi Linn Loo, Priscilla Foo,Winnie Wong,Sharon Pok,
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Zhiguang Xiao,Bianca Sperl,Silvia Gärtner, Tatiana Nedelko, Elvira Stacher-Priehse,Axel Ullrich,Pjotr G Knyazev
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