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The focus of my lab is on developing novel neural interfaces as well as investigating the plasticity mechanism of the brain. Our goal is to reveal underlying mechanisms of brain plasticity that lead to functional recovery from stroke, which can provide us with vital insight to develop stimulation-based therapies not only for stroke but also for a broad range of neurological disorders. We use a combination of electrophysiological recordings in behaving animals, real-time detection and manipulation of physiological patterns, and perturbation of neural activity in specific circuits during behavior, to determine causal links between physiological phenomena and therapeutic outcomes. In particular, the unique tool we use is optogenetics since it enables us to manipulate neural activity with high spatial and temporal resolution via virally transfected neurons containing light-sensitive ion channels. In addition to its potential for greater spatial resolution and cell-type specificity, this technique offers the significant advantage of artifact-free electrophysiological recording during stimulation. This novel use of optogenetics offers new opportunities to create sophisticated closed-loop stimulation and recording paradigms, and helps us to understand the role of the basic physiological and therapeutic phenomena.
研究兴趣
论文共 58 篇作者统计合作学者相似作者
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bioRxiv : the preprint server for biology (2024)
Journal of visualized experiments : JoVE (2024)
bioRxiv : the preprint server for biology (2023)
Sergio Montalvo Vargo,Tiphaine Belloir, Ibrahim Kimukin,Zabir Ahmed,Devon J. Griggs,Noah Stanis,Azadeh Yazdan-Shahmorad,Maysamreza Chamanzar
NERpp.1-6, (2023)
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ICASSP 2023 - 2023 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP)pp.1-5, (2023)
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Gratianne Rabiller,Zachary Ip, Shahram Zarrabian,Hongxia Zhang,Yoshimichi Sato,Azadeh Yazdan-Shahmorad,Jialing Liu
bioRxiv : the preprint server for biologypp.0-0, (2023)
Brain Stimulationno. 1 (2023): 387-387
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Tiphaine Belloir, Sergio Montalgo-Vargo,Zabir Ahmed,Devon J Griggs, Shawn Fisher,Timothy Brown,Maysamreza Chamanzar,Azadeh Yazdan-Shahmorad
iScienceno. 1 (2022): 105866-105866
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