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We are interested in how cell proliferation and differentiation is regulated. In one project we study ADP-ribosylation, a posttranslational modification (PTM) that involves the transfer of ADP-ribose from NAD+ onto substrate proteins. Using the oncoprotein MYC we characterized ARTD10 as a novel interaction partner and defined ARTD10 as the first intracellular mono-ADP-ribosyltransferase. ARTD10 uses substrate-assisted catalysis to modify substrates. We have now identified substrates of ARTD10, established that it controls cell proliferation and apoptosis, and found that ARTD10 regulates the NF-kB signaling pathway. Together, these and other findings highlight the importance of mono-ADP-ribosylation for cell physiology. Further work addresses the biological role of ARTD10 in innate immunity and in tumorigenesis using molecular and cell biological approaches and mouse models.
In a second project we study the regulation of keratinocyte differentation. Atopic dermatitis (AD), a chronic disease with increasing prevalance, results in skin barrier defects. The expression of IL-31 is increased in skin lesions and serum of AD patients and correlates with disease severity. Moreover IL-31 interferes with keratinocyte differentiation in tissue culture. We study the molecular consequences of IL-31 signaling and target genes in 3-dimensional organotypic skin models. Future work will focus on identifying the relevant molecular targets and verifying the functional consequence as well as addressing the therapeutical relevance of the targets.
In a second project we study the regulation of keratinocyte differentation. Atopic dermatitis (AD), a chronic disease with increasing prevalance, results in skin barrier defects. The expression of IL-31 is increased in skin lesions and serum of AD patients and correlates with disease severity. Moreover IL-31 interferes with keratinocyte differentiation in tissue culture. We study the molecular consequences of IL-31 signaling and target genes in 3-dimensional organotypic skin models. Future work will focus on identifying the relevant molecular targets and verifying the functional consequence as well as addressing the therapeutical relevance of the targets.
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Scientific Reportsno. 1 (2023): 22565-22565
Lisa Weixler, Nonso Josephat Ikenga,Jim Voorneveld, Guelcan Aydin,Timo M. H. R. Bolte,Jeffrey Momoh, Mareike Buetepage,Alexandra Golzmann,Bernhard Luescher,Dmitri Filippov,Roko Zaja,Karla L. H. Feijs
biorxiv(2022)
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