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个人简介
Our research focuses on mechanisms underlying the regulation of gene expression and how these mechanisms are disrupted in human diseases and disorders. Most of our research is directed at understanding how alternative splicing is regulated and integrated with other layers of gene expression to control fundamental biological processes. For example, we have discovered alternative splicing "switches" with critical roles in the regulation of transcriptional programs required for neural and embryonic stem cell fate. More recently, we have discovered and characterized a highly conserved alternative splicing regulatory network comprising 3-27 nt neuronal microexons, and have provided evidence that the disruption of this network represents a common mechanism underlying autism spectrum disorders.
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论文共 242 篇作者统计合作学者相似作者
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Raymond W Wong, Ahalya Balachandran, Peter K Cheung,Ran Cheng,Qun Pan,Peter Stoilov,P Richard Harrigan,Benjamin J Blencowe,Donald R Branch,Alan Cochrane
Zuyao Ni,Nujhat Ahmed,Syed Nabeel-Shah, Xinghua Guo,Shuye Pu, Jingwen Song,Edyta Marcon,Giovanni L Burke,Amy Hin Yan Tong,Katherine Chan,Kevin C H Ha,Benjamin J Blencowe,
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Debashish Ray,Kaitlin U. Laverty,Arttu Jolma,Kate Nie,Reuben Samson,Sara E. Pour, Cyrus L. Tam, Niklas von Krosigk,Syed Nabeel-Shah,Mihai Albu,Hong Zheng,Gabrielle Perron,
Scientific Reportsno. 1 (2023): 1-15
MOLECULAR CELLno. 23 (2023): 4222-4238.e10
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