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Research Summary
Early mammalian development is a remarkably plastic period during which only a few cells are present and these are directly exposed to their external maternal environment. The microenvironment can influence the molecular pathways directing self-renewal, differentiation and reprogramming, which can transmit through subsequent cell cycles and rewire the entire developmental program. Our lab studies the fundamental principles that regulate phenotypic, metabolic, and morphogenetic processes in early embryonic patterning; and, the causal mechanisms when these dynamic processes go awry. We combine studies involving mouse and human embryos, and their in vitro 3-dimensional stem cell models to investigate how adaptive plasticity directs developmental programming and, the impacts this have on long-term health and disease. By breaking down and building up these stem cell models of early embryos, hidden mechanisms regarding mammalian embryogenesis and the developmental origins of disease can be uncovered.
Research Interests
Embryonic and Fetal Development; Human Development; Stem Cells; Pluripotent Stem Cells; Bioengineering
Early mammalian development is a remarkably plastic period during which only a few cells are present and these are directly exposed to their external maternal environment. The microenvironment can influence the molecular pathways directing self-renewal, differentiation and reprogramming, which can transmit through subsequent cell cycles and rewire the entire developmental program. Our lab studies the fundamental principles that regulate phenotypic, metabolic, and morphogenetic processes in early embryonic patterning; and, the causal mechanisms when these dynamic processes go awry. We combine studies involving mouse and human embryos, and their in vitro 3-dimensional stem cell models to investigate how adaptive plasticity directs developmental programming and, the impacts this have on long-term health and disease. By breaking down and building up these stem cell models of early embryos, hidden mechanisms regarding mammalian embryogenesis and the developmental origins of disease can be uncovered.
Research Interests
Embryonic and Fetal Development; Human Development; Stem Cells; Pluripotent Stem Cells; Bioengineering
研究兴趣
论文共 40 篇作者统计合作学者相似作者
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Joshua Hislop, Qi Song, Kamyar Keshavarz F.,Amir Alavi, Rayna Schoenberger,Ryan LeGraw,Jeremy J. Velazquez, Tahere Mokhtari, Mohammad Naser Taheri,Matthew Rytel,Susana M. Chuva de Sousa Lopes,Simon Watkins,
Natureno. 7998 (2024): 367-376
Developmental Cell (2024)
Dominica Cao,Liangwen Zhong,Anupama Hemalatha, Jenna Bergmann,Andy L Cox,Valentina Greco,Berna Sozen
bioRxiv : the preprint server for biology (2023)
Joshua Hislop,Amir Alavi, Qi Song, Rayna Schoenberger,Kamyar Keshavarz F,Ryan LeGraw,Jeremy Velazquez, Tahere Mokhtari, Mohammad Nasser Taheri, Matthew Rytel,Susana M Chuva de Sousa Lopes,Simon Watkins,
bioRxiv : the preprint server for biology (2023)
Monique Pedroza,Seher Ipek Gassaloglu,Nicolas Dias,Liangwen Zhong, Tien-Chi Jason Hou,Helene Kretzmer,Zachary D. Smith,Berna Sozen
Natureno. 7983 (2023): 574-583
Seminars in Cell & Developmental Biology (2022): 44-57
biorxiv(2021)
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