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Peptides; membrane protein trafficking; cuproenzymes; neurons; pituitary peptides seem to have preceded the 'classical' transmitters as the nervous system developed - creatures like Hydra and Drosophila utilize peptides to control key developmental decisions. Beginning with our work on proopiomelanocortin and the coordinate biosynthesis of ACTH and the opioid peptide beta-endorphin, I have been fascinated with the effort that neurons and endocrine cells devote to the biosynthesis, storage and regulated secretion of peptides. As we have learned more about the specific enzymes involved in the biosynthesis of peptides, we have learned important questions to ask about how these enzymes function in cells and in the whole animal.We have focused a great deal of our effort on the process of peptide amidation. This seemingly trivial modification to the COOH-terminus of peptides often turns out to be essential for their biological activity.
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论文共 350 篇作者统计合作学者相似作者
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Giampaolo Trivellin,Adrian Daly,Laura C. Hernández-Ramírez,Elisa Araldi,Christina Tatsi,Ryan K. Dale, Gus Fridell, Ayush Mittal,Fabio R. Faucz,James R. Iben,Tianwei Li,Eleonora Vitali,
medRxiv (Cold Spring Harbor Laboratory) (2023)
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Giampaolo Trivellin,Adrian F Daly,Laura C Hernandez-Ramirez,Elisa Araldi,Christina Tatsi,Ryan K Dale, Gus Fridell, Arjun Mittal,Fabio R Faucz,James R Iben,Tianwei Li,Eleonora Vitali,
Frontiers in endocrinology (2023): 1166076
biorxiv(2021)
Encyclopedia of Biological Chemistry IIIpp.88-104, (2021)
Journal of clinical cardiologyno. 4 (2021): 75-80
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