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The primary interest of my laboratory is in the area of cytokines as regulators of tumor cell growth. The specific aims of our Cytokine Research section are as follows: (a) identification of novel antiproliferative agents that are specific to tumor cells and (b) investigation of mechanisms by which tumor cells develop resistance to cytokines and examination of methods to overcome this resistance.
In collaboration with Human Genome Sciences (Boston, MA), we identified several novel cytokines and cytokine receptors that are members of the TNF and TNF receptor superfamily, respectively. We also discovered that genes regulated by the transcription factor NF-kappaB may play a major role in resistance to apoptosis induced by TNF and certain chemotherapeutic agents. Since NF-kappaB also regulates the genes involved in tumor proliferation and metastasis, we demonstrated that several known anticarcinogenic agents are potent inhibitors of NF-kappaB activation. Our results also indicated that the early steps in the pathway leading to apoptosis and NF-kappaB activation overlap.
In collaboration with Human Genome Sciences (Boston, MA), we identified several novel cytokines and cytokine receptors that are members of the TNF and TNF receptor superfamily, respectively. We also discovered that genes regulated by the transcription factor NF-kappaB may play a major role in resistance to apoptosis induced by TNF and certain chemotherapeutic agents. Since NF-kappaB also regulates the genes involved in tumor proliferation and metastasis, we demonstrated that several known anticarcinogenic agents are potent inhibitors of NF-kappaB activation. Our results also indicated that the early steps in the pathway leading to apoptosis and NF-kappaB activation overlap.
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Current opinion in oncologyno. 6 (2003): 405-411
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