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The Baker Lab studies how the structure and mechanics of the tissue microenvironment influence fundamental biological processes including cell migration, proliferation, and matrix synthesis. To do so, we develop tunable biomaterials that mimic the 3D and fibrous nature of native ECMs, can be dynamically remodeled by cells, and have the potential to be scaled to implantable tissues directly. Combined with molecular tools, stem cell technologies, live imaging, and microfabrication/microfluidic approaches, these materials help us to understand the physical interactions between cells and their surroundings. We apply mechanistic insights from these studies to improve the treatment of ECM-mediated diseases such as fibrosis and cancer and to engineer tissues for organ replacement therapies.
Research interests: Mechanobiology
Research Areas: Bio-MEMS and Microfluidics, Biomaterials, Molecular and Cellular Biomechanics, Tissue Engineering and Regenerative Medicine
Research interests: Mechanobiology
Research Areas: Bio-MEMS and Microfluidics, Biomaterials, Molecular and Cellular Biomechanics, Tissue Engineering and Regenerative Medicine
研究兴趣
论文共 121 篇作者统计合作学者相似作者
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BIOACTIVE MATERIALS (2024): 292-303
Linqing Li, Megan E. Griebel,Marina Uroz, Saniya Yesmin Bubli,Keith A. Gagnon,Britta Trappmann,Brendon M. Baker,Jeroen Eyckmans,Christopher S. Chen
ADVANCED FUNCTIONAL MATERIALSno. 17 (2024)
Hiba Kobeissi, Xining Gao,Samuel J. DePalma,Jourdan K. Ewoldt, Miranda C. Wang,Shoshana L. Das,Javiera Jilberto,David Nordsletten,Brendon M. Baker, Christopher S. Chen,Emma Lejeune
arxiv(2024)
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Roshan Kumar,Victor Vitvitsky, Apichaya Sethaudom,Rashi Singhal,Sumeet Solanki, Sydney Alibeckoff,Harrison L. Hiraki,Hannah N. Bell,Anthony Andren,Brendon M. Baker,Costas A. Lyssiotis,Yatrik M. Shah,
Nature Chemical Biologypp.1-11, (2024)
Computer Methods in Biomechanics and Biomedical Engineering II Lecture Notes in Computational Vision and Biomechanicspp.213-223, (2024)
Hiba Kobeissi,Javiera Jilberto,M. Cagatay Karakan, Xining Gao,Samuel J. DePalma,Shoshana L. Das,Lani Quach, Jonathan Urquia,Brendon M. Baker,Christopher S. Chen,David Nordsletten,Emma Lejeune
PLOS ONEno. 3 (2024): e0298863-e0298863
Christopher D. Davidson,Firaol S. Midekssa,Samuel J. DePalma, Jordan L. Kamen,William Y. Wang, Danica Kristen P. Jayco, Megan E. Wieger,Brendon M. Baker
ADVANCED SCIENCEno. 3 (2024): n/a-n/a
Robert N. Kent III,Maggie E. Jewett, Trevor P. Buck, Mohamed Said, LeeAnn A. Hold,Eileen A. Crawford,Megan L. Killian,Adam C. Abraham,Alice H. Huang,Brendon M. Baker
ADVANCED HEALTHCARE MATERIALSpp.e2400529-e2400529, (2024)
Samuel J. DePalma, Javiera Jillberto, Austin E. Stis, Darcy D. Huang,Jason Lo, Christopher D. Davidson, Aamilah Chowdhury,Maggie E. Jewett, Hiba Kobeissi,Christopher S. Chen, Emma Lejeune,Adam S. Helms,
biorxiv(2023)
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