基本信息
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职业迁徙
个人简介
the 1970's, I developed methods to detect the penicillin-sensitive enzymes of peptidoglycan synthesis as penicillin-binding proteins (PBPs) and identified the individual target enzymes inhibited by penicillins and other beta-lactam antibiotics when they kill bacteria. Subsequently, I worked on mechanisms of resistance to penicillin and identified the role of interspecies recombination and the formation of mosaic genes in the emergence of resistance in pneumococci, gonococci and meningococci, and then became interested more generally in the extent of homologous recombination in bacteria and in their population and evolutionary biology. More recently we developed new tools for identifying strains of bacterial pathogens - particularly multilocus sequence typing (MLST) - and have been interested in bacterial speciation.
I am now semi-retired and have closed my laboratory, but we work with collaborators on the use of genome sequencing to follow the spread of MRSA within and between hospitals, and of gonorrhoea in sexual networks. With David Aanensen, we developed, and continue to improve, the Android mobile phone software application, EpiCollect, which is widely used for complex data collection projects, particularly field studies in ecology and global public health.
PUBLICATIONS
De Smet B, Sarovich DS, Price EP, et al., 2015, Whole-genome sequencing confirms that Burkholderia pseudomallei multilocus sequence types common to both Cambodia and Australia are due to homoplasy., J Clin Microbiol, Vol:53, Pages:323-326
DOIAuthor Web Link
McRobb E, Kaestli M, Price EP, et al., 2014, Distribution of Burkholderia pseudomallei in Northern Australia, a Land of Diversity, Applied and Environmental Microbiology, Vol:80, ISSN:0099-2240, Pages:3463-3468
DOIAuthor Web Link
Aanensen DM, Huntley DM, Menegazzo M, et al., 2014, EpiCollect+: linking smartphones to web applications for complex data collection projects., F1000res, Vol:3
DOIAuthor Web Link
Hudson LO, Murphy CR, Spratt BG, et al., 2013, Diversity of Methicillin-Resistant Staphylococcus aureus (MRSA) Strains Isolated from Inpatients of 30 Hospitals in Orange County, California, Plos One, Vol:8, ISSN:1932-6203
DOIAuthor Web Link
Holden MTG, Hsu L-Y, Kurt K, et al., 2013, A genomic portrait of the emergence, evolution, and global spread of a methicillin-resistant Staphylococcus aureus pandemic, Genome Research, Vol:23, ISSN:1088-9051, Pages:653-664
研究兴趣
论文共 33 篇作者统计合作学者相似作者
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mag(2013)
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Hajo Grundmann,David M Aanensen, Van Den Wijngaard Cc,Brian G Spratt,Dag Harmsen,Alexander W Friedrich
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