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Today’s biomaterials and medical devices save lives and improve the quality of life for millions. These are part of a $300 billion industry. However, there are also complications that stem from these devices, often associated with non-physiologic (fibrotic) healing, initiation of inflammation, thrombosis and/or bacterials colonization. The University of Washington Engineered Biomaterials (UWEB) program (an NSF Engineering Research Center) asks if healing and performance of implanted biomaterials might be engineered to be similar to the healing of normal wounds? To do this, we study the basic biology of wound healing in collaboration with colleagues who are expert in these areas. Then, we, as engineers, translate the basic science discoveries into technologies appropriate to improve the performance of medical devices.
We engineer new biomaterial surfaces using a wide range of technologies. For example, radio-frequency plasma deposition (a method borrowed from microelectronics) can readily place interesting thin films on existing medical device surfaces. These films can be used in the precision immobilization of key signaling molecules. We also synthesize new polymers that can be biostable, environmentally responsive, biodegradable and/or porous (i.e., scaffolds). The new surfaces and materials made in our laboratory are studied in contact with proteins, blood, living cells and tissues (in vivo and in vitro).
Recently, there has been considerable interest in tissue engineering in my laboratory. Tissue engineering exploits all the above principles in the context of tissue and organ reconstruction and regeneration. Specific tissue engineering projects in the Ratner lab have aimed toward heart muscle, esophagus, bone, cartilage, bladder, vagina and cornea. Another new project seeks to model cancer tumor microenvironments using tissue engineering ideas.
Today’s biomaterials and medical devices save lives and improve the quality of life for millions. These are part of a $300 billion industry. However, there are also complications that stem from these devices, often associated with non-physiologic (fibrotic) healing, initiation of inflammation, thrombosis and/or bacterials colonization. The University of Washington Engineered Biomaterials (UWEB) program (an NSF Engineering Research Center) asks if healing and performance of implanted biomaterials might be engineered to be similar to the healing of normal wounds? To do this, we study the basic biology of wound healing in collaboration with colleagues who are expert in these areas. Then, we, as engineers, translate the basic science discoveries into technologies appropriate to improve the performance of medical devices.
We engineer new biomaterial surfaces using a wide range of technologies. For example, radio-frequency plasma deposition (a method borrowed from microelectronics) can readily place interesting thin films on existing medical device surfaces. These films can be used in the precision immobilization of key signaling molecules. We also synthesize new polymers that can be biostable, environmentally responsive, biodegradable and/or porous (i.e., scaffolds). The new surfaces and materials made in our laboratory are studied in contact with proteins, blood, living cells and tissues (in vivo and in vitro).
Recently, there has been considerable interest in tissue engineering in my laboratory. Tissue engineering exploits all the above principles in the context of tissue and organ reconstruction and regeneration. Specific tissue engineering projects in the Ratner lab have aimed toward heart muscle, esophagus, bone, cartilage, bladder, vagina and cornea. Another new project seeks to model cancer tumor microenvironments using tissue engineering ideas.
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Le Zhen,Elina Quiroga,Sharon A. Creason, Ningjing Chen, Tanmay R. Sapre, Jassica M. Snyder,Sarah L. Lindhartsen, Brendy S. Fountaine,Michael C. Barbour,Syed Faisal,Alberto Aliseda,Brian W. Johnson,
biorxiv(2024)
Biomedical Engineering Advances (2023): 100081
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Acta biomaterialia (2023): 119-132
BME Frontiers (2023): 0003
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