基本信息
浏览量:103
职业迁徙
个人简介
Charles Saul Lieber (February 13, 1931 – March 1, 2009) was a clinical nutritionist who established that excess alcohol consumption can cause cirrhosis of the liver even in subjects who have an adequate diet, contradicting then-current scientific opinion.
Lieber was born on February 13, 1931, in Antwerp, Belgium, and was forced to flee with his family to France, and later Switzerland, as World War II bloomed. He spent most of the war with a Swiss family that had taken him in from a refugee camp. He attended college in Belgium after the war, where a portion of his stomach was removed due to complications of a peptic ulcer. At the University of Brussels school of medicine, his ulcer led him to investigate its causes, prior to his graduation in 1955.
He continued research there after graduation, until a fellowship took him to Boston City Hospital and Harvard University. There he was troubled by the belief in the profession that cirrhosis in alcoholics was caused by malnutrition and not alcohol itself, having seen alcoholics in Belgium who had liver disease even with a proper diet and based on research by Dr. Charles Best (co-discoverer of insulin) that showed that alcohol had no greater an effect in rats than sugar water. Lieber pursued Best's theory that excessive amounts of alcohol damaged the liver.
He was hired by Manhattan's Bellevue Hospital Center in 1963, where he successfully pleaded for a grant from the National Institutes of Health which would be used for his investigations on alcohol in baboons. He was admitted to the faculty of Bronx Veterans Affairs Medical Center and was appointed as a professor at the Mount Sinai School of Medicine in 1968, where he identified the biochemical processes used in the human body to metabolize alcohol. In a 1974 study, he showed that baboons who had been given a normal diet combined with the equivalent of about 750 millilitres (26 imp fl oz; 25 US fl oz) of alcohol daily for four years experienced cirrhosis, contradicting medical dogma that inadequate nutrition combined with alcoholism caused the disease. Other research showed that the effect of even social drinking on the liver can cause it to create toxic substances, increasing the sensitivity of even social drinkers to acetaminophen, anesthetics and certain solvents.
研究兴趣
论文共 442 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Diseases of the Liver and Biliary Tractpp.85-91, (2015)
The Baboon in Biomedical Researchpp.285-301, (2009)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn