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Part of our current research is focused on understanding microtubule organisation and dynamics, and how these properties are harnessed for the life and health of cells. Microtubule regulation and organisation by a plethora of proteins is adapted to different functional contexts. We use a combination of biochemistry, biophysics and structural biology by cryo-electron microscopy (cryo-EM) to elucidate the mechanisms by which kinesin motors and microtubule associated proteins interact with and regulate microtubules.
Another strand of our research is focused on the actin cytoskeleton and the Arp2/3 complex which is essential for stimulating dynamic branched actin networks in multiple cellular processes. Funded by an ERC Synergy grant in collaboration with Dr Michael Way (The Francis Crick Institute, London, UK) and Dr Edgar Gomes (Institute of Molecular Medicine, Lisbon, Portugal), we are exploring the mechanisms of Arp2/3 isoform complexes at molecular, cellular and physiological hierarchies of organisation, with a particular focus on muscle development, function and disease.
Another strand of our research is focused on the actin cytoskeleton and the Arp2/3 complex which is essential for stimulating dynamic branched actin networks in multiple cellular processes. Funded by an ERC Synergy grant in collaboration with Dr Michael Way (The Francis Crick Institute, London, UK) and Dr Edgar Gomes (Institute of Molecular Medicine, Lisbon, Portugal), we are exploring the mechanisms of Arp2/3 isoform complexes at molecular, cellular and physiological hierarchies of organisation, with a particular focus on muscle development, function and disease.
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论文共 133 篇作者统计合作学者相似作者
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bioRxiv (Cold Spring Harbor Laboratory) (2024)
Nature Communicationsno. 1 (2023): 1-1
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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semanticscholar(2022)
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EMPIAR dataset (2022)
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Rita Tewari, Anthony A. Holder,Mathieu Brochet,Karine G. Le Roch,Carolyn A. Moores,Sue Vaughan,Declan Brady, Zeinab Chahine,Steven Abel,David J Ferguson,Ravish Rashpa,Mohammad Zeeshan
crossref(2022)
Tianyang Liu,Fiona Shilliday,Alexander D. Cook, Mohammad Zeeshan, Declan Brady,Rita Tewari,Colin J. Sutherland,Anthony J. Roberts,Carolyn A. Moores
biorxiv(2022)
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