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Our research is focused on lymphocyte proliferative disorders. We have identified a novel diagnostic entity of clonal B lymphocytosis and chromosomal translocation t(2;7) linking CDK6 to IGK locus in B-cell neoplasia. As part of NSERC Strategic network, we have been developing nanoparticle probes for targeting leukemia cells.
Molecular and cellular mechanisms of lymphoproliferative disorders. We contributed to the characterization of clonal B lymphocytosis as a novel diagnostic entity. We are focused on clinical, phenotypical, molecular and cytogenetic features of the non-CLL type clonal lymphocytosis of undetermined significance and clonal progression from benign lymphocytosis to clinical malignancies. We perform immunophenotypic study and demonstrated essential CD5 expression to separate it from chronic lymphocytic leukemia and largely clarified the controversy on CD5- atypical CLL. Our findings contributed to the guideline for diagnosis of monoclonal B-cell lymphocytosis.
Molecular and cellular mechanisms of lymphoproliferative disorders. We contributed to the characterization of clonal B lymphocytosis as a novel diagnostic entity. We are focused on clinical, phenotypical, molecular and cytogenetic features of the non-CLL type clonal lymphocytosis of undetermined significance and clonal progression from benign lymphocytosis to clinical malignancies. We perform immunophenotypic study and demonstrated essential CD5 expression to separate it from chronic lymphocytic leukemia and largely clarified the controversy on CD5- atypical CLL. Our findings contributed to the guideline for diagnosis of monoclonal B-cell lymphocytosis.
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Benjamin Ober-Reynolds,Chen Wang, Justin M. Ko,Eon J. Rios, Sumaira Z. Aasi,Mark M. Davis, Anthony E. Oro,William J. Greenleaf
biorxiv(2022)
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