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Dr. Cirelli’s research is aimed at investigating the fundamental mechanisms of sleep regulation by using a combination of molecular and genetic approaches. By performing whole-genome expression profiling studies in different species her laboratory has characterized hundreds of genes whose expression changes in neurons and glial cells in sleep relative to wakefulness. This analysis has identified specific cellular processes that are favored by sleep and impaired by sleep deprivation. In a second, complementary approach Dr. Cirelli’s laboratory has been performing a large-scale mutagenesis screening for sleep phenotypes in Drosophila. Several mutant fly lines that have much reduced sleep or are resistant to sleep deprivation have been found. The characterization of the genes mutated in these lines has identified key cellular pathways involved in the regulatory mechanisms of sleep and its functional consequences. Overall, these molecular and genetic studies have shown that sleep need is strongly related to experience-dependent plasticity during wake.
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EUROPEAN JOURNAL OF NEUROSCIENCEno. 4 (2024): 502-525
JOURNAL OF INTEGRATIVE NEUROSCIENCEno. 1 (2024): 24-24
Matias Lorenzo Cavelli, Rong Mao,Graham Findlay, Kort Driessen,Tom Bugnon,Giulio Tononi,Chiara Cirelli
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