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Mary R. Shanley,Yuka Miura,Christopher A. Guevara,Amanda Onoichenco, Rufina Kore, Emine Ustundag, Rania Darwish, Lauren Renzoni, Ashley Urbaez, Ella Blicker, Alec Seidenberg,Teresa A. Milner,
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Sebastian Bozlee,Christopher Guevara, David Smyth
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Christopher Guevara, Kumayl Alloo, Romario Thomas, Alexander Tielemans, Kyomi Blake, Jamal Magoti,Swati Gupta, Alexandra Magee,Deanna Benson,George Huntley
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s. The fibers are locally closed subschemes of products of Ishii's ``territories,\" projective moduli schemes parametrizing subalgebras of a fixed algebra. The setting for our stratification is a new moduli stack $\\mathscr{E}_{g,n}$ of ``equinormalized curves\" which is a minor modification of the moduli space of all reduced, connected curves. We prove algebraicity of substacks $\\mathscr{E}^{\\delta,\\delta'}_{g,n}$ where invariants $\\delta, \\delta'$ are fixed, coarsely stratifying $\\mathscr{E}_{g,n}$, then refine this to the desired stratification $\\mathscr{E}_\\Gamma$. A key technical ingredient is the introduction of the invariant $\\delta'$ which allows us to ensure conductors commute with base change. ","authors":[{"name":"Sebastian Bozlee"},{"id":"6329324830241ae3e5af5969","name":"Christopher Guevara"},{"name":"David Smyth"}],"create_time":"2023-07-20T04:57:40.904Z","hashs":{"h1":"smasc"},"id":"64b8b1bd3fda6d7f062b9959","num_citation":0,"pdf":"https:\u002F\u002Fcz5waila03cyo0tux1owpyofgoryroob.aminer.cn\u002F13\u002F06\u002F8D\u002F13068D02982462B1DFD26086F171221F.pdf","title":"A stratification of moduli of arbitrarily singular curves","urls":["https:\u002F\u002Fopenalex.org\u002FW4384919714","https:\u002F\u002Farxiv.org\u002Fabs\u002F2307.10013"],"venue":{"info":{"name":"arXiv (Cornell University)"}},"versions":[{"id":"64b8b1bd3fda6d7f062b9959","sid":"2307.10013","src":"arxiv","year":2023},{"id":"65793ce8939a5f4082162706","sid":"W4384919714","src":"openalex","year":2023}],"year":2023},{"authors":[{"id":"6329324830241ae3e5af5969","name":"Christopher Guevara","org":"Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY USA","orgs":["Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY USA"]},{"name":"Kumayl Alloo","org":"Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY USA","orgs":["Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY USA"]},{"name":"Romario Thomas","org":"Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY USA","orgs":["Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY USA"]},{"name":"Alexander Tielemans","org":"Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY USA","orgs":["Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY USA"]},{"name":"Kyomi Blake","org":"Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY USA","orgs":["Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY USA"]},{"name":"Jamal Magoti","org":"Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY USA","orgs":["Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY USA"]},{"id":"654e7b3a8a47b64923452d85","name":"Swati Gupta","org":"Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY USA","orgs":["Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY USA"]},{"name":"Alexandra Magee","org":"Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY USA","orgs":["Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY USA"]},{"id":"53f45b3edabfaee02ad6abda","name":"Deanna Benson","org":"Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY USA","orgs":["Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY USA"]},{"id":"53f42f7fdabfaeb22f422e7b","name":"George Huntley","org":"Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY USA","orgs":["Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY USA"]}],"create_time":"2023-11-09T08:34:49.515Z","hashs":{"h1":"dvacv","h2":"sm","h3":"cpdlm"},"id":"64d489f13fda6d7f06b6e77e","issn":"0893-133X","num_citation":0,"pages":{"end":"283","start":"282"},"title":"Differential Vulnerabilities to Acute and Chronic Variable Stress in Mice Carrying a Parkinson's Disease-Linked LRRK2-G2019S Mutation","urls":["http:\u002F\u002Fwww.webofknowledge.com\u002F"],"venue":{"info":{"name":"NEUROPSYCHOPHARMACOLOGY"},"volume":"47"},"versions":[{"id":"64d489f13fda6d7f06b6e77e","sid":"WOS:000897934700541","src":"wos","year":2022}],"year":2022},{"abstract":"Clinical evidence suggests that rapid and sustained antidepressant action can be attained with a single exposure to psychedelics. However, the biological substrates and key mediators of psychedelics' enduring action remain unknown. Here, we show that a single administration of the psychedelic DOI produces fast-acting effects on frontal cortex dendritic spine structure and acceleration of fear extinction via the 5-HT2A receptor. Additionally, a single dose ofDOI leads to changes in chromatin organization, particularly at enhancer regions of genes involved in synaptic assembly that stretch for days after the psychedelic exposure. These DOIinduced alterations in the neuronal epigenome overlap with genetic loci associated with schizophrenia, depression, and attention deficit hyperactivity disorder. Together, these data support that epigenomicdriven changes in synaptic plasticity sustain psychedelics' long-lasting antidepressant action but also warn about potential substrate overlap with genetic risks for certain psychiatric conditions.","authors":[{"id":"561c63be45ce1e596465d64f","name":"Mario de la Fuente Revenga","org":"Virginia Commonwealth Univ, Dept Physiol & Biophys, Sch Med, Richmond, VA 23298 USA","orgid":"5f71b28e1c455f439fe3cac5","orgs":["Virginia Commonwealth Univ, Dept Physiol & Biophys, Sch Med, Richmond, VA 23298 USA","Virginia Commonwealth Univ, Virginia Inst Psychiat & Behav Genet, Richmond, VA 23298 USA"]},{"id":"6379875cf789b382be9ac9d0","name":"Bohan Zhu","org":"Virginia Tech, Dept Chem Engn, Blacksburg, VA 24061 USA","orgs":["Virginia Tech, Dept Chem Engn, Blacksburg, VA 24061 USA"]},{"id":"6329324830241ae3e5af5969","name":"Christopher A Guevara","org":"Icahn Sch Med Mt Sinai, Nash Family Dept Neurosci, New York, NY 10029 USA","orgs":["Icahn Sch Med Mt Sinai, Nash Family Dept Neurosci, New York, NY 10029 USA","Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY 10029 USA"]},{"id":"62e4a4afd9f204418d6cc743","name":"Lynette B Naler","org":"Virginia Tech, Dept Chem Engn, Blacksburg, VA 24061 USA","orgs":["Virginia Tech, Dept Chem Engn, Blacksburg, VA 24061 USA"]},{"id":"64fa784e26b5833b384d9a26","name":"Justin M Saunders","org":"Virginia Commonwealth Univ, Dept Physiol & Biophys, Sch Med, Richmond, VA 23298 USA","orgid":"5f71b28e1c455f439fe3cac5","orgs":["Virginia Commonwealth Univ, Dept Physiol & Biophys, Sch Med, Richmond, VA 23298 USA"]},{"id":"62e8ae21d9f20422f0ba6c19","name":"Zirui Zhou","org":"Virginia Tech, Dept Chem Engn, Blacksburg, VA 24061 USA","orgs":["Virginia Tech, Dept Chem Engn, Blacksburg, VA 24061 USA"]},{"id":"64fa784e26b5833b384d9a27","name":"Rudy Toneatti","org":"Virginia Commonwealth Univ, Dept Physiol & Biophys, Sch Med, Richmond, VA 23298 USA","orgid":"5f71b28e1c455f439fe3cac5","orgs":["Virginia Commonwealth Univ, Dept Physiol & Biophys, Sch Med, Richmond, VA 23298 USA"]},{"id":"562be03a45cedb3398b70e02","name":"Salvador Sierra","org":"Virginia Commonwealth Univ, Dept Physiol & Biophys, Sch Med, Richmond, VA 23298 USA","orgid":"5f71b28e1c455f439fe3cac5","orgs":["Virginia Commonwealth Univ, Dept Physiol & Biophys, Sch Med, Richmond, VA 23298 USA"]},{"id":"562dcb9545ce1e5967ad8b69","name":"Jennifer T Wolstenholme","org":"Virginia Commonwealth Univ, Dept Pharmacol & Toxicol, Sch Med, Richmond, VA 23298 USA","orgid":"5f71b28e1c455f439fe3cac5","orgs":["Virginia Commonwealth Univ, Dept Pharmacol & Toxicol, Sch Med, Richmond, VA 23298 USA"]},{"id":"53f438bcdabfaedf43595d24","name":"Patrick M Beardsley","org":"Virginia Commonwealth Univ, Dept Pharmacol & Toxicol, Sch Med, Richmond, VA 23298 USA","orgid":"5f71b28e1c455f439fe3cac5","orgs":["Virginia Commonwealth Univ, Dept Pharmacol & Toxicol, Sch Med, Richmond, VA 23298 USA","Virginia Commonwealth Univ, Ctr Biomarker Res & Precis Med, Richmond, VA 23298 USA"]},{"id":"53f42f7fdabfaeb22f422e7b","name":"George W Huntley","org":"Icahn Sch Med Mt Sinai, Nash Family Dept Neurosci, New York, NY 10029 USA","orgs":["Icahn Sch Med Mt Sinai, Nash Family Dept Neurosci, New York, NY 10029 USA","Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY 10029 USA"]},{"email":"changlu@vt.edu","id":"62aaae5fd9f2040d085ca0a3","name":"Chang Lu","org":"Virginia Tech, Dept Chem Engn, Blacksburg, VA 24061 USA","orgs":["Virginia Tech, Dept Chem Engn, Blacksburg, VA 24061 USA"]},{"email":"javier.maeso@vcuhealth.org","id":"53f432e4dabfaee1c0a79b1b","name":"Javier González-Maeso","org":"Virginia Commonwealth Univ, Dept Physiol & Biophys, Sch Med, Richmond, VA 23298 USA","orgid":"5f71b28e1c455f439fe3cac5","orgs":["Virginia Commonwealth Univ, Dept Physiol & Biophys, Sch Med, Richmond, VA 23298 USA"]}],"citations":{"google_citation":40},"create_time":"2021-10-24T13:50:43.228Z","doi":"10.1016\u002Fj.celrep.2021.109836","hashs":{"h1":"pespa","h3":"sepm"},"id":"617538c25244ab9dcb38a4e8","issn":"2211-1247","keywords":["5-HT2A receptor","GPCR","depression","epigenomics","hallucinogens","psychedelics","psychosis","schizophrenia","serotonin (5-HT)","synaptic plasticity"],"lang":"en","num_citation":71,"pages":{"end":"109836","start":"109836"},"title":"Prolonged epigenomic and synaptic plasticity alterations following single exposure to a psychedelic in mice","update_times":{"u_a_t":"2021-10-29T17:13:41.731Z","u_c_t":"2023-05-04T12:58:34.174Z","u_v_t":"2022-05-26T13:36:00.371Z"},"urls":["https:\u002F\u002Fwww.ncbi.nlm.nih.gov\u002Fpubmed\u002F34686347","https:\u002F\u002Fdoaj.org\u002Farticle\u002F43705a14b3dc480c8aba3ee0cb75a2bd","http:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS2211124721013000","https:\u002F\u002Fwww.biorxiv.org\u002Fcontent\u002F10.1101\u002F2021.02.24.432725v1.full","http:\u002F\u002Fwww.webofknowledge.com\u002F"],"venue":{"info":{"name":"CELL REPORTS"},"issue":"3","volume":"37"},"venue_hhb_id":"5eb60b88edb6e7d53c0a7cae","versions":[{"id":"617538c25244ab9dcb38a4e8","sid":"34686347","src":"pubmed","vsid":"101573691","year":2021},{"id":"6197dd295244ab9dcbd1b103","sid":"10.1101\u002F2021.02.24.432725","src":"biorxiv","year":2021},{"id":"628d28ab5aee126c0f4ee510","sid":"WOS:000709243200006","src":"wos","vsid":"CELL 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