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Dr. Pirozzi is currently working on utilizing those mutations identified in the human genetic screens for immunotherapeutic purposes. He has generated a series of orthotopic intracranial injection-based immune-competent animal models for which he is actively investigating the impact the mutations have on the tumor-immune microenvironment and whether the tumor-immune microenvironment can be manipulated to promote an anti-tumor response. Specifically, his most recently funded Department of Defense Idea Award with Special Focus entails understanding the impact mutant IDH1 is having on the Th17 T cell lineage and whether this can be exploited for therapeutic purposes.
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论文共 13 篇作者统计合作学者相似作者
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PLOS ONEno. 3 (2024): e0299820-e0299820
bioRxiv (Cold Spring Harbor Laboratory) (2023)
biorxiv(2022)
Nanotechnologyno. 27 (2019): 275101-275101
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