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We have broad interests in Biotechnology, especially bacterial control. Historically, our understanding of bacterial physiology and development of antibiotics have been focused on planktonic (free-swimming) cells. However, the vast majority of bacteria in nature exist in surface-attached highly hydrated structures comprising of a polysaccharide matrix secreted by the bound bacterial cells, collectively known as biofilms. With up to 1000 times higher tolerance to antibiotics and disinfectants compared to their planktonic counterparts, deleterious biofilms cause serious problems such as chronic infections in humans as well as persistent corrosion and equipment failure in industry. Biofilms are blamed for billions of dollars of losses and more than 45,000 deaths annually in the U.S. alone. Despite the well-recognized significance of biofilms, the biofilm research is still in its infancy. With the efficacy of antibiotics and disinfectants being intrinsically limiting, new approaches especially those with synergistic effects are desired.Compared to the deleterious biofilms, which cause serious problems in both medical and engineering environments, biofilms of environmentally friendly bacteria have promising applications. Due to their intrinsic tolerance to toxic agents, such biofilms may provide promising solutions to currently unmet challenges such as the high cost in biofuel production due to the low tolerance of microbes to fermentation products and difficulties in bioremediation of toxic contaminants.
In the Biofilm Engineering Laboratory, we have broad interests in biofilm research including genetic basis of multidrug resistance, biofilm control by engineering smart surfaces and biomaterials, development of novel biofilm and persister inhibitors, as well as biofilm engineering for biofuel production.
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论文共 109 篇作者统计合作学者相似作者
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Noreen J. Hickok,Bingyun Li,Ebru Oral,Sebastian A. J. Zaat, David A. Armbruster,Gerald J. Atkins, Antonia F. Chen,Debora C. Coraca-Huber,Tianhong Dai,Edward M. Greenfield, Rajendra Kasinath,Matthew Libera,
JOURNAL OF ORTHOPAEDIC RESEARCH (2024)
Journal of Biological Chemistrypp.107231-107231, (2024)
Noreen J. Hickok,Bingyun Li,Ebru Oral,Sebastian A. J. Zaat, David A. Armbruster,Gerald J. Atkins,Antonia F. Chen,Debora C. Coraca-Huber,Tianhong Dai,Edward M. Greenfield, Rajendra Kasinath,Matthew Libera,
JOURNAL OF ORTHOPAEDIC RESEARCHno. 3 (2024): 512-517
NANOMATERIALSno. 1 (2024): 44
ACS Omegano. 41 (2023): 37798-37807
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