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My main interest is in Lewy body diseases, collectively the second most common form of neurodegenerative disease after Alzheimer's disease, that are characterised by accumulations of the protein alpha-synuclein in some neurons termed Lewy bodies. Although Lewy bodies are thought to have a central role in Lewy body diseases, they do not form in all cell types and the relationship between Lewy bodies and cell death is imperfect. Much of my current work is attempting to understand factors that mediate cellular vulnerability to Lewy body formation and cell death, with a particular focus on cell-autonomous factors that may enhance or diminish such vulnerability and the potential influence of different species of alpha-synuclein. The aim of these efforts is to better understand how changes to the brain induce the symptoms of Lewy body disease, with important implications for designing disease-relevant model systems and neuroprotective agents.
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Zoe Catchpole,Annabelle E. Hartanto,Tetsushi Kataura,Pawel Palmowski,Andrew Porter,Kristina Ulicna, Robert McFarland, Angela Pyle, Robert Taylor, Kate S. Harris,Viktor I. Korolchuk,Daniel Erskine
bioRxiv (Cold Spring Harbor Laboratory) (2024)
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Phoebe Conod, Nicola Charlesworth,Pawel Palmowski,Andrew Porter,Lauren Walker,Omar El-Agnaf,Viktor Korolchuk,Tiago F. Outeiro,Daniel Erskine
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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