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Professor Harris leads clinical research on the prevention and management of CKD including studies on peritoneal and haemodialysis for the management of patients with end-stage kidney disease. Additionally, he directs a laboratory research program focused on understanding the pathophysiology of CKD progression and more recently, the use of cellular and other novel approaches to slow CKD progression. He has been involved in numerous investigator- and industry-initiated clinical trials, the results of which have contributed significantly to clinical practice and informed Australian and international guidelines. Chief among these was the IDEAL trial (New England Journal of Medicine 2010) which showed planned early initiation of dialysis in patients with stage V CKD was not associated with an improvement in survival or clinical outcomes, challenging prevailing clinical practice and leading to changes to guidelines on dialysis.In recent years he has collaborated in the Blue Mountains Eye Study studying eye and other diseases in CKD. Currently he is a chief investigator in a randomised controlled trial aimed at slowing the progression of renal failure due to autosomal dominant polycystic kidney disease (ADPKD) and CKD-FIX, a trial of allopurinol in the slowing of kidney disease progression.
His laboratory research on the pathophysiology of CKD progression has led to major findings including highlighting the importance of renal cell hypermetabolism, proteinuria, pro-inflammatory changes in renal cells, oxidative stress-related injury, NFkB, epithelial mesenchymal transition, matrix metalloproteinases and interstitial inflammation, in disease progression. His paper on treating renal disease with macrophages was editorialised in Kidney International, and his article on regulatory cells was reviewed in Nature Clinical Practice Rheumatology. Current projects are investigating the mechanisms underlying kidney fibrosis development to help identify potential therapeutic targets. Other studies aim to define the role of regulatory cells such as renal mononuclear phagocytes in CKD progression.
Professor Harris? team also is investigating novel therapies such as DNA vaccination and regulatory lymphocytes, macrophages and dendritic cells, to slow disease progression.
His laboratory research on the pathophysiology of CKD progression has led to major findings including highlighting the importance of renal cell hypermetabolism, proteinuria, pro-inflammatory changes in renal cells, oxidative stress-related injury, NFkB, epithelial mesenchymal transition, matrix metalloproteinases and interstitial inflammation, in disease progression. His paper on treating renal disease with macrophages was editorialised in Kidney International, and his article on regulatory cells was reviewed in Nature Clinical Practice Rheumatology. Current projects are investigating the mechanisms underlying kidney fibrosis development to help identify potential therapeutic targets. Other studies aim to define the role of regulatory cells such as renal mononuclear phagocytes in CKD progression.
Professor Harris? team also is investigating novel therapies such as DNA vaccination and regulatory lymphocytes, macrophages and dendritic cells, to slow disease progression.
Research Interests
Papers共 442 篇Author StatisticsCo-AuthorSimilar Experts
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Gopala Rangan,Margaret Allman-Farinelli,Neil Boudville, Mangalee Fernando, Imad Haloob,David C H Harris,Carmel M Hawley,Karthik Kumar,David W Johnson,Vincent W Lee,Jun Mai,Anna Rangan,Simon D Roger, Priyanka Sagar,Kamal Sud,Vicente Torres,Eswari Vilayur
Clinical kidney journalno. 7 (2024): sfae159-sfae159
Nephrology Dialysis Transplantationno. Supplement_1 (2024)
Brendon L Neuen,Aminu K Bello,Adeera Levin,Meaghan Lunney,Mohamed A Osman,Feng Ye,Gloria E Ashuntantang,Ezequiel Bellorin-Font,Mohammed Benghanem Gharbi,Sara Davison,Mohammad Ghnaimat,Paul Harden,Vivekanand Jha,Kamyar Kalantar-Zadeh,Peter G Kerr,Scott Klarenbach,Csaba P Kovesdy,Valerie Luyckx,Shahrzad Ossareh,Jeffrey Perl,Harun Ur Rashid,Eric Rondeau,Emily J See,Syed Saad,Laura Sola,Irma Tchokhonelidze,Vladimir Tesar,Kriang Tungsanga,Rumeyza Turan Kazancioglu,Angela Yee-Moon Wang,Chih-Wei Yang,Alexander Zemchenkov,Ming-Hui Zhao,Kitty J Jager,Fergus J Caskey,Vlado Perkovic,Kailash K Jindal,Ikechi G Okpechi,Marcello Tonelli,John Feehally,David C Harris,David W Johnson
PLOS global public healthno. 2 (2023): e0001467-e0001467
TRIALSno. 1 (2023)
Sneha Amin,Irene Sangadi,Margaret Allman-Farinelli,Sunil Badve,Neil Boudville,Helen Coolican,Susan Coulshed,Sheryl Foster,Mangalee Fernando,Imad Haloob,David C. H. Harris,Carmel M. Hawley,Jane Holt,Martin Howell,Karthik Kumar,David W. Johnson,Vincent W. Lee,Jun Mai,Anna Rangan,Simon D. Roger, Kamal Sud, Vicente Torres, Eswari Vilayur, Gopala K. Rangan
Sayanthooran Saravanabavan,Alexandra Munt,Sunil Badve,Neil Boudville,Helen Coolican,Susan Coulshed,Sheryl Foster,Mangalee Fernando,Imad Haloob,David Harris,Carmel Hawley,Jane Holt,Martin Howell,Karthik Kumar,David Johnson,Vincent Lee,Maureen Lonergan,Jun Mai,Simon Roger,Kamal Sud,Allison Tong,Vicente Torres,Eswari Vilayur,Gopala Rangan
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#Papers: 441
#Citation: 15912
H-Index: 66
G-Index: 116
Sociability: 7
Diversity: 0
Activity: 3
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