基本信息
浏览量:74
职业迁徙
个人简介
Dr. Ellison’s research centers on effects of diet on blood pressure, on mechanisms of salt transport by the kidney, on the genetic basis of human hypertension and on diuretic treatment of edema. A long-term focus of his research is the thiazide-sensitive NaCl cotransporter (NCC). His early studies helped define the distal convoluted tubule of the kidney and how mutations of NCC can lead to Gitelman syndrome. Dr. Ellison showed that the antibiotic trimethoprim causes hyperkalemia in humans by disrupting transport along the distal convoluted tubule and showed that chronic treatment with high doses of loop diuretics causes hypertrophy of the distal nephron, work that is now being translated to help improve diuretic treatment of edema. Dr. Ellison has been a leader in defining how mutations in a novel kinase pathway cause Familial Hyperkalemic Hypertension by altering distal salt transport and has defined how a high potassium diet reduces kidney salt transport. Finally, his group has demonstrated that the immunosuppressive drug tacrolimus causes hyperkalemia and hypertension by activating the NCC; this work has been translated to an ongoing clinical trial. All of his work melds basic and clinical approaches and has been published in top journals including Nature Medicine, the Journal of Clinical Investigation, Cell Metabolism, and the Journal of the American Society of Nephrology.
研究兴趣
论文共 356 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Xiao-Tong Su,Jeremiah V. Reyes, Anne E. Lackey, Hasan Demirci,Sebastian Bachmann, Yujiro Maeoka,Ryan J. Cornelius,James A. McCormick,Chao-Ling Yang,Hyun Jun Jung,Paul A. Welling,Jonathan W. Nelson,
Journal of Clinical and Translational Scienceno. s1 (2024): 18-19
Conrad Macon,David H Ellison
Kidney360 (2024)
Hypertension (Dallas, Tex. : 1979)no. 1 (2024): 126-137
Kidney360 (2024)
HYPERTENSIONno. 3 (2024): 415-425
Journal of Clinical and Translational Scienceno. s1 (2024): 155-155
Veena S. Rao,Juan B. Ivey-Miranda,Zachary L. Cox,Julieta Moreno-Villagomez,Christopher Maulion,Lavanya Bellumkonda,John Chang, M. Paul Field, Daniel R. Wiederin,Javed Butler,Sean P. Collins,Jeffrey M. Turner,
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGYno. 2 (2024): 189-201
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn