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RESEARCH INTERESTS
Structure and Function of Anti-Retroviral Host Proteins
I am interested in how HIV and other retroviruses interact with components of the host cell during infection. These interactions govern both the ability of the virus to reproduce, and the ability of the cell to block and contain infection. Of particular interest are members of the TRIM protein family that can recognise retroviral components within the cell and then act to block the viral lifecycle, disrupting infection. We aim to characterise these proteins and the interactions they make using X-ray crystallography, small-angle X-ray scattering and other biophysical techniques.
How to metal based chemotherapeutics target proteins?
Platinum compounds form the foundation of many treatment regimens for cancer. However, these compounds are promiscuous lacking the specificity of other chemotherapeutic compounds. This results in off target and side-effects that limit their usability in treatment. We are interested in how metal-based compounds interact with proteins, and understanding how we can generate specificity to improve treatment options for cancer patients.
研究兴趣
论文共 91 篇作者统计合作学者相似作者
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Chemistry (Weinheim an der Bergstrasse, Germany)no. 28 (2024): e202400268-e202400268
JOURNAL OF CHEMINFORMATICSno. 1 (2024)
Michael Barnett,Jully P. Pinheiro,Jeremy Keown,Jacob C. Biboy,Joe J. Gray, Ioana-Wilhelmina Lucinescu,Waldemar J. Vollmer,Robert Hirt,Augusto J. Simoes-Barbosa,David Goldstone
Foodsno. 22 (2023): 4072-4072
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Shujing Xu,Lin Sun,Michael Barnett,Xujie Zhang,Dang Ding, Anushka Gattu, Dazhou Shi, Jamie R. H. Taka,Wenli Shen,Xiangyi Jiang,Simon Cocklin,Erik De Clercq,Christophe Pannecouque,David C. Goldstone,Xinyong Liu,Alexej Dick,Peng Zhan
Journal of medicinal chemistryno. 23 (2023): 16303-16329
Acta Crystallographica Section A Foundations and Advancesno. a2 (2023)
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作者统计
#Papers: 92
#Citation: 2525
H-Index: 24
G-Index: 50
Sociability: 6
Diversity: 3
Activity: 25
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