基本信息
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职业迁徙
个人简介
Research Interests
Aging; Cardiovascular health; dermatology; extracellular matrix; Granzymes; inflammation; proteases; Pulmonary health; remodelling; Repair; Tissue injury; Wound healing
Over the past 20 years, Dr. Granville’s research program has focused on identifying mechanisms that underlie tissue injury and therapeutic targets that can be exploited to reduce injury and/or promote healing. His research is presently centered on how aging and immobility affect tissue injury, inflammation, and repair in different types of tissues. Dr. Granville’s research team is investigating a family of immune cell-secreted proteases known as granzymes (granule-secreted enzymes) and their role in aging and chronic inflammation. Dr. Granville identified that granzymes are elevated and contribute to the pathogenesis of conditions associated with impaired healing and inflammation, including skin injuries, autoimmune skin diseases, and cardiovascular and pulmonary diseases. In order to study granzymes in a diverse set of indications, Dr. Granville collaborates with a network of expert clinical and scientific collaborators. Dr. Granville is currently translating his discoveries into the development and commercialization of novel, first-in-class therapeutics.
At ICORD, Dr. Granville’s team is expanding on their discoveries in tissue injury, inflammation, and repair, and applying their expertise to spinal cord injury, pressure injury, dermatological conditions, and aging-related disorders. Dr. Granville also continues to lead an established research program examining the role of granzymes in cardiovascular and pulmonary diseases. Dr. Granville’s team is currently one of few groups in the world studying granzyme K in inflammation and disease.
研究兴趣
论文共 206 篇作者统计合作学者相似作者
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Mohamed Ben-Eltriki,Amir Reza Ahmadi,Yuya Nakao,Kalyan Golla, Flavia Lakschevitz,Lari Haekkinen,David J. Granville,Hugh Kim
JOURNAL OF PERIODONTAL RESEARCHno. 1 (2024): 94-103
Nature Reviews Rheumatologypp.1-16, (2024)
Anna Gleave,David J Granville
Biomoleculesno. 2 (2023): 388-388
Mohamed Ben-Eltriki,Amir Reza Ahmadi, Yuya Nakao,Kalyan Golla, Flavia Lakschevitz,Lari Häkkinen,David J Granville,Hugh Kim
Journal of periodontal researchno. 1 (2023): 94-103
Ying Shiang Lim, Aisha G. Lee,Xiaoping Jiang, Jason M. Scott,Adjoa Cofie,Sandeep Kumar,Dania Kennedy,David J. Granville,Haina Shin
CELL REPORTSno. 4 (2023)
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