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Dr. Rush’s pioneering work in the use of surveillance biopsies in transplantation made him the first to report the high prevalence of subclinical rejection in renal transplant recipients. With this research, he has changed the understanding of the link between early chronic pathologic changes and long-term graft survival. Dr. Rush’s seminal work in this field has lowered the threshold for the diagnosis of rejection and had an impact on the design of clinical trials evaluating immunosuppression protocols for renal transplant patients. Dr. Rush’s work in translational medicine has also directly led to the improvement in renal allograft survival and patient care in the Transplant Manitoba-Adult Renal Program, where over 1,000 transplants have been performed to date. The international profile of his research program has led to changes in clinical practice in many transplant programs worldwide.
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