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I am interested in applications of synthetic chemistry to homogeneous catalysis (especially asymmetric catalysis) and to sustainable energy.
We have developed several catalytic methods for asymmetric synthesis of chiral phosphines, which are a useful class of ligands for metal-catalyzed asymmetric synthesis, including (a) asymmetric hydrophosphination, in which a chiral Pt(0) complex catalyzes enantioselective addition of a P-H bond across a C=C bond (b) asymmetric phosphination, where a chiral Pd(0) complex catalyzes enantioselective cross-coupling of an aryl iodide and a secondary phosphine, and (c) Pt- or Cu-catalyzed enantioselective alkylation of secondary phosphines, which can be used to prepare chiral bidentate diphosphines. More recently, we have discovered new routes to highly enantiomerically enriched P-stereogenic phosphiranes and secondary phosphine oxides (SPOs). Development of these new reactions is guided by extensive mechanistic studies and characterization of the catalytic intermediates. This work involves synthesis of inorganic, organometallic, and organic (especially organophosphorus) compounds.
In another application of asymmetric catalysis, we are studying metal-catalyzed hydration of nitriles, a useful process in the pharmaceutical industry. This project uses our new chiral SPOs in chiral metal complexes designed to selectively bind and hydrate chiral nitriles.
We have developed several catalytic methods for asymmetric synthesis of chiral phosphines, which are a useful class of ligands for metal-catalyzed asymmetric synthesis, including (a) asymmetric hydrophosphination, in which a chiral Pt(0) complex catalyzes enantioselective addition of a P-H bond across a C=C bond (b) asymmetric phosphination, where a chiral Pd(0) complex catalyzes enantioselective cross-coupling of an aryl iodide and a secondary phosphine, and (c) Pt- or Cu-catalyzed enantioselective alkylation of secondary phosphines, which can be used to prepare chiral bidentate diphosphines. More recently, we have discovered new routes to highly enantiomerically enriched P-stereogenic phosphiranes and secondary phosphine oxides (SPOs). Development of these new reactions is guided by extensive mechanistic studies and characterization of the catalytic intermediates. This work involves synthesis of inorganic, organometallic, and organic (especially organophosphorus) compounds.
In another application of asymmetric catalysis, we are studying metal-catalyzed hydration of nitriles, a useful process in the pharmaceutical industry. This project uses our new chiral SPOs in chiral metal complexes designed to selectively bind and hydrate chiral nitriles.
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Jorge A. Garduno, Andrew J. Sasser, Hannah J. Sexton, Russell P. Hughes,David S. Glueck,Arnold L. Rheingold
ORGANOMETALLICSno. 3 (2024): 381-394
Ryan M. Tipker,Russell P. Hughes,David S. Glueck, Heather A. Spinney, Michael A. Brammer,Arnold L. Rheingold
ORGANOMETALLICSno. 3 (2024): 427-431
ORGANOMETALLICSno. 13 (2023): 1448-1453
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microLife (2023)
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ORGANOMETALLICSno. 13 (2022): 1721-1730
Organometallicsno. 12 (2022): 1475-1479
Comprehensive Heterocyclic Chemistry IVpp.464-505, (2022)
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