My research focuses on how inflammation regulates the function of neurons, particularly the synaptic connections between neurons. We have discovered that inflammatory signals are used to maintain normal levels of neuronal activity (homeostasis), and this is achieved through the regulation of synaptic strength. We are investigating how this contributes to the change in brain function observed during many disorders, as most neurological diseases are accompanied by inflammation. In particular, we are investigating the compensatory mechanisms that may be engaged during neurodegenerative disease and psychiatric disorders such as addiction and autism.