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I have successfully pioneered technology that enables targeting antigens secreted by luminal tissues, opening a new class of cancer tissue-specific targets including widely used circulating biomarkers. This is a considerable advance over previous implementations of RIT as disease specific secreted antigens are targeted, and radiotherapeutic doses are delivered intracellularly for maximum effect as close to the nucleus as possible. The technology builds on recent advances in our understanding of neonatal Fc-receptor (FcRn) biology. FcRn selectively traffics IgG1/antigen complexes from the exterior of the cell to lysosome compartments, while unbound IgG1 are released back into the blood circulation. My innovative antibody platform demonstrates exquisite affinity and specificity for androgen receptor (AR) governed enzymes hK2 and PSA, two well-characterized enzymes exclusively expressed in both prostate and AR-positive breast carcinomas. I have, together with my biotech start-up company, successfully humanized, cGMP produced, and tested the hK2-targeting antibody in non-human primates. A phase 1 study has been initiated in collaboration with a major pharmaceutical company (ClinicalTrials.gov: NCT04116164). I have, in parallel with these laboratory efforts, conducted population- based clinical research studies focused on risk factors and biomarkers related to definitive end-points in non- screened cohorts. I have worked alongside world-renowned experts to author several paradigm-shifting publications on prostate-specific kallikreins and their applications as biomarkers for prostate cancer.
研究兴趣
论文共 132 篇作者统计合作学者相似作者
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Claire M Storey,Mohamed Altai,Katharina M Lueckerath,Wahed Zedan,Henan Zhu,Marija Trajkovic-Arsic, Julie E Park,Norbert Peekhaus, Jens Siveke,Henrik Lilljebjorn,Diane Abou, Haley L Marks,
biorxiv(2024)
Journal of nuclear medicine : official publication, Society of Nuclear Medicineno. 2 (2024): 245-251
Journal of nuclear medicine : official publication, Society of Nuclear Medicineno. 7 (2023): 1062-1068
Diane S. Abou,Mark S. Longtine,Amanda Fears,Nadia Benabdallah,Ryan Unnerstall, Hannah E. Johnston,Kyu–Hwan Shim, A. Hasson,Hanwen Zhang,David Ulmert,Floriane Mangin,Şerife Özen,
The Journal of Nuclear Medicineno. 7 (2023): 1062-1068
Handbook of Nuclear Medicine and Molecular Imaging for Physicistspp.255-303, (2022)
biorxiv(2022)
D. Abou,M. Longtine, A. Hasson, A. Fears, R. Unnerstall, C. Storey,M. Altai, N. Peekhaus, D. Tatum, D. Magda,R. Wahl,D. Ulmert,
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Hanwen Zhang,Diane Abou,Peng Lu, Abbie Meghan Hasson,Alexandria Villmer,Nadia Benabdallah,Wen Jiang,David Ulmert, Sean Carlin,Buck E. Rogers, Norman F. Turtle,Michael R. McDevitt,
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