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Practising physician at one of Manchester's University Hospitals with expertise in fungal infections, particularly aspergillosis, antifungal resistance, the treatment of fungal infection and infection in the immunocompromised patient。Graduate of Guys Hospital London in 1980, with training in medicine, paediatrics, gastroenteroloy, haematology, infectious diseases and clinical microbiology, including a 3 year fellowship at Stanford University with Professor David Stevens (1987-1990)。
Director of National Aspergillosis Centre, based at University Hospital of South Manchester, Wythenshawe Hospital.Co-ordinator of the International Genome Sequencing project for Aspergillus fumigatus (funded by NIH, Wellcome Trust and Spanish government) 1997-2005。 Founder and Editor of Aspergillus website (1998-) Consultant (current or past) to multiple pharmaceutical companies with regard to antifungal drug discovery including Merck, Pfizer, Schering Plough, Oxford Glycosciences and Astellas. Founder of F2G Ltd, an antifungal drug discovery company spun out from Manchester University (1998- 2012). Founder and Chief Medical Officer of Myconostica (acquired by Trinity Biotech), developing and commercialising molecular diagnostics for fungal disease (2006-2011). Chairman of several international conferences (Trends in Invasive Fungal Infection (x3 1993, 1997 and 1999; Advances against Aspergillosis x6 2004, 2006, 2008, 2010 and 2012, 2014: Aspergillus Genetics and Genomes Focus Meeting 2004, and other smaller meetings) and sessions at major congresses. MacFarlane Burnett Lecturer to the Australasian Society of Infectious Diseases, 2005.
Professor of Infectious Diseases in Global Health and Consultant in Infectious Diseases and Medical Mycology, Wythenshawe Hospital and University of Manchester and President of the Global Action Fund for Fungal Infections.
Graduate of Guy's Hospital, University of London, 1980. Clinical training in internal medicine, infectious diseases, microbiology, paediatrics and haematology in London, Glasgow and California (1980-1990). Research training at the MRC Clinical Research Centre, Harrow, UK (1985-87) and Stanford University, California, USA (1987-1990). Granted a personal chair by Manchester University in 2005.
My clinical interests are in fungal diseases, immunocompromised patients and complex hospital infection problems.
My research interests relate to antifungal susceptibility testing and resistance, pathogenesis of invasive aspergillosis, clinical studies of antifungal agents, Aspergillus genomics and the burden of fungal infections globally and in different countries.
In addition to continuing clinical practice and research, I was instrumental in starting a biotechnology company called F2G. F2G has identified several new promising antifungal drug candidates , one of which is shortly to be studied in human volunteers. I retain a very small number of F2G shares, but no longer consult for it.
In 2006, I founded Myconostica, a molecular diagnostics spin-out of The University of Manchester. Myconostica developed and commercialised rapid real-time molecular diagnostic tests for Aspergillus and Pneumocystis, before being acquired by Lab21 in May 2011. IÂ advise Trinity Biotech (who now handle Myconostica products) on clinical aspects of fungal diagnosis as a consultantI also advise T2 Biosystems (diagnostics), GSK (Vaccines) and give talks on behalf of Astellas, Pfizer and Gilead. In 2013,I became President of the Global Action Fund for Fungal infections.
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