Wendy Dean
教授
Department of Biochemistry & Molecular Biology
Cumming School of Medicine, University of Calgary/Alberta Children’s Hospital Research Institute, University of Calgary/Epigenetics Programme, The Babraham Institute/Department of Cell Biology and Anatomy, Cumming School of Medicine, University of Calgary
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Research summary
The genetic code supplies instructions for all the 200 cell types of the adult human. All these cells arise from the fertilised egg. One blueprint with many interpretations, giving the awe-inspiring arc from embryo to adult organism. This orchestration is the role of epigenome. Epigenetic instructions are both rigid, keeping cellular identity fixed throughout a healthy lifespan, and flexible responding to environmental, nutritional and metabolic requirements from development and throughout all life. Many layers of the epigenome are required to regulate gene expression in a meticulous fashion supplying sufficient gene products at the right time and the right place.
Among the most essential cells produced in the development of the organism are those that will become eggs and sperm. These cells cross the generations and arise at early stages of development. As such, during pregnancy, multiple generations all exist simultaneously and the life experiences of one may affect the immediate, next and future generations. Examples are found in age related health and disease processes. Understanding the mechanisms is still in its infancy. However, new tools and therapies are available to probe these challenges to learning about and ensuring children’s health, the basis of a healthy society.
The genetic code supplies instructions for all the 200 cell types of the adult human. All these cells arise from the fertilised egg. One blueprint with many interpretations, giving the awe-inspiring arc from embryo to adult organism. This orchestration is the role of epigenome. Epigenetic instructions are both rigid, keeping cellular identity fixed throughout a healthy lifespan, and flexible responding to environmental, nutritional and metabolic requirements from development and throughout all life. Many layers of the epigenome are required to regulate gene expression in a meticulous fashion supplying sufficient gene products at the right time and the right place.
Among the most essential cells produced in the development of the organism are those that will become eggs and sperm. These cells cross the generations and arise at early stages of development. As such, during pregnancy, multiple generations all exist simultaneously and the life experiences of one may affect the immediate, next and future generations. Examples are found in age related health and disease processes. Understanding the mechanisms is still in its infancy. However, new tools and therapies are available to probe these challenges to learning about and ensuring children’s health, the basis of a healthy society.
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Physiological reviewsno. 4 (2023): 2523-2560
European Neuropsychopharmacology (2023): S102-S102
Rebecca M Green,Lucas D Lo Vercio,Andreas Dauter,Elizabeth C Barretto,Jay Devine,Marta Vidal-García,Marta Marchini,Samuel Robertson, Xiang Zhao,Anandita Mahika, M Bilal Shakir,Sienna Guo,
bioRxiv : the preprint server for biology (2023)
Simon Andrews,Christel Krueger, Maravillas Mellado-Lopez,Myriam Hemberger,Wendy Dean,Vicente Perez-Garcia,Courtney W. Hanna
Nature communicationsno. 1 (2023): 371-12
Bethany N. Radford, Xiang Zhao, Tali Glazer, Malcolm Eaton,Danielle Blackwell,Shuhiba Mohammad,Lucas Daniel Lo Vercio,Jay Devine,Tali Shalom-Barak,Benedikt Hallgrimsson,James C. Cross,Henry M. Sucov,
Advances in experimental medicine and biology (2022): 211-238
Jay Devine,Marta Vidal-García,Wei Liu, Amanda Neves,Lucas D. Lo Vercio,Rebecca M. Green,Heather A. Richbourg,Marta Marchini,Colton M. Unger, Audrey C. Nickle,Bethany Radford,Nathan M. Young,
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