Estrin's research activities include technologies for caregiving, immersive health, small data, participatory sensing, and Public Interest Technology.
Estrin's honors include: ACM Athena Lecture (2006), Anita Borg Institute's Women of Vision Award for Innovation (2007), the IEEE Internet Award (2017), and MacArthur Fellowship (2018). She is an elected member of the American Academy of Arts and Sciences (2007), the National Academy of Engineering (2009), and the National Academy of Medicine (2019).