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Leukocyte entry into tissue is usually triggered by pathological stimuli such as physical injury or infectious microorganisms. It is the starting event that initiates the process of inflammation and that controls the continuation of inflammatory reactions. Understanding its molecular basis will allow to interfere with and modulate the often harmful consequences of the inflammatory process. Within this context we are investigating the molecular mechanism that enables leukocytes to overcome the blood vessel wall mainly formed by endothelial cells, a basement membrane and associated perivascular cells. We are presently focusing on novel endothelial membrane proteins that control the endothelial barrier function during leukocyte extravasation.
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Cell and Tissue Researchno. 1 (2024): 81-103
JOURNAL OF VASCULAR RESEARCHno. SUPP1 (2023): 59-59
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Dietmar Vestweber,Lena Claesson-Welsh,Donald M. McDonald, Timothy Williams,Martin A. Schwartz,Joshua Scallan,Felicity N. E. Gavins,Jaap van Buul,Jennifer Gamble, Matthew Vadas,Brian H. Annex,Steven R. Messe,
Nature Cardiovascular Researchno. 12 (2023): 1120-1124
Nature communicationsno. 1 (2023): 5837-23
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Steven Clasper,Daniel Royston, Dilair Baban,Yihai Cao, Stephan Ewers, Stefan Butz,Dietmar Vestweber,David G. Jackson
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