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We are focusing on development and homeostatic turnover of immune cells and organ tissues to understand the driving forces and control mechanisms of cell fate decision. We investigate a variety of systems which prominently show constant turnover, lineage plasticity, and response to perturbations in terms of cell differentiation dynamics. For example, we investigate the role of the hematopoietic niche, i.e., the effect of a varying microenvironments, such as fetal liver and bone marrow, on blood cell differentiation, and compare to aberrant cell fate decision upon diseases such as leukemia.
As a complementary system we are studying plasticity and turnover of epithelial cells and their crosstalk with tissue-resident immune cells in the liver, the central metabolic organ of the human body. The liver exhibits high regenerative capacity, driven by complex interactions with the immune, endothelial, and mesenchymal cell compartment.
In our studies we are aiming to address basic research questions, such as the identification of the molecular mechanisms underpinning robust cell differentiation, but also aim at translating our findings into clinically relevant novel therapeutic approaches.
As a complementary system we are studying plasticity and turnover of epithelial cells and their crosstalk with tissue-resident immune cells in the liver, the central metabolic organ of the human body. The liver exhibits high regenerative capacity, driven by complex interactions with the immune, endothelial, and mesenchymal cell compartment.
In our studies we are aiming to address basic research questions, such as the identification of the molecular mechanisms underpinning robust cell differentiation, but also aim at translating our findings into clinically relevant novel therapeutic approaches.
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论文共 81 篇作者统计合作学者相似作者
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Marie Czech, Sophia Schneider, Nina Peltokangas,Nadia El Khawanky,Sakhila Ghimire,Geoffroy Andrieux, Jan Huelsduenker,Mate Krausz,Michele Proietti,Lukas M. Braun, Tamina Rueckert,Marlene Langenbach,
SCIENCE TRANSLATIONAL MEDICINEno. 735 (2024): eadi1501-eadi1501
Anja Nusser, Sagar,Jeremy B. Swann, Brigitte Krauth,Dagmar Diekhoff,Lesly Calderon,Christiane Happe,Dominic Grün,Thomas Boehm
Natureno. 8000 (2024): E17-E17
引用5浏览0引用
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EMBO reportsno. 8 (2023): e56233-e56233
引用1浏览0WOS引用
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Milas Ugur, R. Jacob Labios, Chloe Fenton,Konrad Knöpper, Katarzyna Jobin,Fabian Imdahl,Gosia Golda, Kathrin Hoh,Anika Grafen,Tsuneyasu Kaisho,Antoine-Emmanuel Saliba,Dominic Grün,
Sophia M Hochrein,Hao Wu,Miriam Eckstein, Laura Arrigoni,Josip S Herman,Fabian Schumacher,Christian Gerecke,Mathias Rosenfeldt,Dominic Grün,Burkhard Kleuser,Georg Gasteiger,Wolfgang Kastenmüller,
Cell metabolismno. 4 (2022): 516-532.e11
Nature Cell Biologyno. 7 (2022): 1038-1048
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