Ed S. Lein - Human Cell Types, Allen Institute for Brain Science

基本信息

Career Trajectory

Bio

Ed Lein received the BS degree in biochemistry from Purdue University in 1993 and the PhD degree in neurobiology from the University of California at Berkeley in 1999. His postdoctoral work at the Salk Institute for Biological Studies involved using laser capture microdissection, DNA microarrays, and high throughput in situ hybridization to examine highly specific gene expression in subregions and layers of the hippocampus and neocortex. A focus of his current work at the Allen Institute for Brain Science is utilizing gene expression as a tool to define specific neuronal subtypes in the brain and genetic manipulation of these cells as a means of understanding their roles in higher-level behaviors.

Research Interests

Papers共 220 篇Author StatisticsCo-AuthorSimilar Experts

By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选

Enhancer AAV Toolbox for Accessing and Perturbing Striatal Cell Types and Circuits

Avery C Hunker,Morgan E Wirthlin, Gursajan Gill,Nelson J Johansen,Marcus Hooper,Victoria Omstead,Naz Taskin,Natalie Weed,Sara Vargas,Jacqueline L Bendrick,Bryan Gore,Yoav Ben-Simon,Yeme Bishaw,Ximena Opitz-Araya,Refugio A Martinez,Sharon Way,Bargavi Thyagarajan, M Nathaly Lerma, Will Laird, Otto Sven,Raymond E A Sanchez, Jason R Alexander, Avalon Amaya,Adam Amster, Angela Ayala, Pam M Baker, Tyler Barcelli, Stuard Barta,Darren Bertagnolli, Cameron Bielstein,Prajal Bishwakarma,Jessica Bowlus,Gabriella Boyer,Krissy Brouner, Brittny Casian,Tamara Casper,Anish Bhaswanth Chakka,Rushil Chakrabarty,Michael Clark, Kaity Colbert,Scott Daniel, Tim Dawe, Maxwell Departee, Peter DiValentin, Nicholas P Donadio,Nadezhda I Dotson,Deepanjali Dwivedi,Tom Egdorf,Tim Fliss,Amanda Gary,Jeff Goldy,Conor Grasso, Erin L Groce, Kathryn Gudsnuk, Warren Han,Zeb Haradon, Sam Hastings, Olivia Helback, Windy V Ho,Cindy Huang,Tye Johnson, Danielle L Jones,Zoe Juneau, Jaimie Kenney, Madison Leibly, Su Li,Elizabeth Liang, Henry Loeffler, Nicholas A Lusk, Zachary Madigan, Jessica Malloy,Jocelin Malone,Rachel McCue,Jose Melchor,John K Mich, Skyler Moosman,Elyse Morin, Robyn Naidoo,Dakota Newman,Kiet Ngo,Katrina Nguyen, Aaron L Oster,Ben Ouellette, Alana A Oyama, Nick Pena,Trangthanh Pham, Elliot Phillips, Christina Pom,Lydia Potekhina,Shea Ransford,Melissa Reding, Dean F Rette, Cade Reynoldson,Christine Rimorin, Ana Rios Sigler, Dana B Rocha,Kara Ronellenfitch,Augustin Ruiz, Lane Sawyer,Josh Sevigny,Nadiya V Shapovalova, Noah Shepard, Lyudmila Shulga,Sherif Soliman,Brian Staats,Michael J Taormina,Michael Tieu, Yimin Wang, Josh Wilkes, Toren Wood,Thomas Zhou,Ali Williford,Nick Dee,Tyler Mollenkopf,Lydia Ng,Luke Esposito,Brian Kalmbach,Shenqin Yao,Jeanelle Ariza,Shoaib Mufti,Kimberly Smith,Jack Waters,Ina Ersing,Marcella Patrick,Hongkui Zeng,Ed S Lein,Yoshiko Kojima, Greg Horwitz, Scott F Owen,Boaz P Levi,Tanya L Daigle,Bosiljka Tasic,Trygve E Bakken,Jonathan T Ting

bioRxiv the preprint server for biology (2024)

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Enrichment of Somatic Cancer Driver Mutations in Alzheimer’s Disease Microglia and Its Association with Neuroinflammation

August Yue Huang,Zinan Zhou,Maya Talukdar, Michael B Miller,Brian Chhouk, Liz Enyenihi, Ila Rosen, Edward Stronge,Boxun Zhao,Dachan Kim, Jaejoon Choi,Sattar Khoshkhoo,Junho Kim,Javier Ganz,Kyle J Travaglini,Mariano I Gabitto,Rebecca D Hodge,Eitan S Kaplan,Ed S Lein,Philip L. De Jager,David A. Bennett, Eunjung Alice Lee,Christopher A Walsh

Alzheimer's &amp Dementia（2024）

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A Suite of Enhancer AAVs and Transgenic Mouse Lines for Genetic Access to Cortical Cell Types

Yoav Ben-Simon,Marcus Hooper, Sujatha Narayan,Tanya Daigle,Deepanjali Dwivedi,Sharon W Way, Aaron Oster,David A Stafford,John K Mich,Michael J Taormina,Refugio A Martinez,Ximena Opitz-Araya, Jada R Roth, Shona Allen, Angela Ayala,Trygve E Bakken, Tyler Barcelli, Stuard Barta,Jacqueline Bendrick,Darren Bertagnolli,Jessica Bowlus,Gabriella Boyer,Krissy Brouner, Brittny Casian,Tamara Casper, Anish B Chakka,Rushil Chakrabarty,Rebecca K Chance, Sakshi Chavan, Maxwell Departee,Nicholas Donadio,Nadezhda Dotson,Tom Egdorf,Mariano Gabitto, Jazmin Garcia,Amanda Gary, Molly Gasperini,Jeff Goldy,Bryan B Gore,Lucas Graybuck, Noah Greisman, Francoise Haeseleer, Carliana Halterman, Olivia Helback,Dirk Hockemeyer,Cindy Huang, Sydney Huff,Avery Hunker,Nelson Johansen,Zoe Juneau,Brian Kalmbach, Shannon Khem, Emily Kussick, Rana Kutsal,Rachael Larsen,Changkyu Lee,Angus Y Lee, Madison Leibly,Garreck H Lenz,Elizabeth Liang,Nicholas Lusk,Jocelin Malone,Tyler Mollenkopf,Elyse Morin,Dakota Newman,Lydia Ng,Kiet Ngo,Victoria Omstead, Alana Oyama,Trangthanh Pham,Christina A Pom,Lydia Potekhina,Shea Ransford, Dean Rette,Christine Rimorin, Dana Rocha,Augustin Ruiz,Raymond E A Sanchez,Adriana Sedeno-Cortes, Joshua P Sevigny,Nadiya Shapovalova, Lyudmila Shulga, Ana R Sigler,La' Akea Siverts,Saroja Somasundaram, Kaiya Stewart,Eric Szelenyi,Michael Tieu, Cameron Trader,Cindy T J van Velthoven,Miranda Walker,Natalie Weed,Morgan Wirthlin, Toren Wood, Brooke Wynalda,Zizhen Yao,Thomas Zhou,Jeanelle Ariza,Nick Dee,Melissa Reding,Kara Ronellenfitch,Shoaib Mufti,Susan M Sunkin,Kimberly A Smith,Luke Esposito,Jack Waters,Bargavi Thyagarajan,Shenqin Yao,Ed S Lein,Hongkui Zeng,Boaz P Levi,John Ngai,Jonathan Ting,Bosiljka Tasic

bioRxiv the preprint server for biology (2024)

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Single-cell Genomics and Regulatory Networks for 388 Human Brains

Prashant S. Emani,Jason J. Liu,Declan Clarke,Matthew Jensen,Jonathan Warrell,Chirag Gupta, Ran Meng,Che Yu Lee,Siwei Xu, Cagatay Dursun,Shaoke Lou,Yuhang Chen,Zhiyuan Chu,Timur Galeev,Ahyeon Hwang, Yunyang Li,Pengyu Ni, Xiao Zhou,Trygve E. Bakken,Jaroslav Bendl,Lucy Bicks, Tanima Chatterjee,Lijun Cheng,Yuyan Cheng,Yi Dai,Ziheng Duan, Mary Flaherty,John F. Fullard, Michael Gancz,Diego Garrido-Martin, Sophia Gaynor-Gillett,Jennifer Grundman, Natalie Hawken, Ella Henry,Gabriel E. Hoffman, Ao Huang,Yunzhe Jiang,Ting Jin,Nikolas L. Jorstad,Riki Kawaguchi,Saniya Khullar, Jianyin Liu, Junhao Liu,Shuang Liu,Shaojie Ma,Michael Margolis, Samantha Mazariegos,Jill Moore,Jennifer R. Moran, Eric Nguyen,Nishigandha Phalke,Milos Pjanic,Henry Pratt,Diana Quintero, Ananya S. Rajagopalan, Tiernon R. Riesenmy, Nicole Shedd, Manman Shi, Megan Spector,Rosemarie Terwilliger,Kyle J. Travaglini,Brie Wamsley,Gaoyuan Wang,Yan Xia,Shaohua Xiao,Andrew C. Yang,Suchen Zheng,Michael J. Gandal,Donghoon Lee,Ed S. Lein,Panos Roussos,Nenad Sestan,Zhiping Weng,Kevin P. White,Hyejung Won,Matthew J. Girgenti,Jing Zhang,Daifeng Wang,Daniel Geschwind,Mark Gerstein

Scienceno. 6698 (2024)

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Distinctive Physiology of Molecularly Identified Medium Spiny Neurons in the Macaque Putamen

Jonathan T. Ting,Nelson J. Johansen,Brian E. Kalmbach,Naz Taskin,Brian Lee, Jason K. Clark, Rennie Kendrick,Lindsay Ng,Cristina Radaelli,Natalie Weed,Rachel Enstrom,Shea Ransford, Ingrid Redford,Sarah Walling-Bell,Rachel Dalley,Michael Tieu,Jeff Goldy,Nik Jorstad,Kimberly Smith,Trygve Bakken,Ed S. Lein, Scott F. Owen

CELL REPORTSno. 11 (2024)

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Ptau‐associated Gene Expression Signatures in the Middle Temporal Gyrus

Victoria M Rachleff,Joseph T Mahoney,Kyle J Travaglini,Mariano I Gabitto,Rebecca D Hodge,C Dirk Keene,Ed S Lein

Alzheimer's &amp Dementia（2024）

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A Multiplex Screening Strategy for Resolving Cell-Type Enhancer-AAV Expression Patterns in the Brain

Avery C. Hunker, John K. Mich,Naz Taskin,Amy Torkelson,Trangthanh Pham, Jeff Goldy,Christine Rimorin,Michael Tieu,Kimberly Smith,Ed S. Lein,Boaz P. Levi,Jonathan T. Ting

MOLECULAR THERAPYno. 4 (2024): 464-464

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Evaluating Methods for the Prediction of Cell Type-Specific Enhancers in the Mammalian Cortex

Nelson J Johansen, Niklas Kempynck,Nathan R Zemke,Saroja Somasundaram,Seppe De Winter,Marcus Hooper,Deepanjali Dwivedi,Ruchi Lohia, Fabien Wehbe,Bocheng Li, Darina Abaffyová,Ethan J Armand, Julie De Man, Eren Can Eksi,Nikolai Hecker,Gert Hulselmans, Vasilis Konstantakos,David Mauduit,John K Mich,Gabriele Partel,Tanya L Daigle,Boaz P Levi,Kai Zhang,Yoshiaki Tanaka,Jesse Gillis,Jonathan T Ting,Yoav Ben-Simon,Jeremy Miller,Joseph R Ecker,Bing Ren,Stein Aerts,Ed S Lein,Bosiljka Tasic,Trygve E Bakken

bioRxiv the preprint server for biology (2024)

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The Commitment of the Human Cell Atlas to Humanity

Ido Amit,Kristin Ardlie, Fabiana Arzuaga,Gordon Awandare,Gary Bader,Alexander Bernier,Piero Carninci,Stacey Donnelly, Roland Eils, R,Henry T Greely,Roderic Guigo,Nir Hacohen,Muzlifah Haniffa, Emily Sarah Kirby,Bartha Maria Knoppers,Arnold Kriegstein,Ed S Lein,Sten Linnarsson, Partha P Majumder,Miriam Merad,Kerstin Meyer,Musa M Mhlanga,Garry Nolan, Ntobeko A B Ntusi,Dana Pe'er, Shyam Prabhakar, Maili Raven-Adams,Aviv Regev,Orit Rozenblatt-Rosen,Senjuti Saha,Andrea Saltzman, Alex K Shalek, Jay W Shin,Henk Stunnenberg,Sarah A Teichmann,Timothy Tickle,Alexandra-Chloe Villani,Christine Wells,Barbara Wold,Huanming Yang,Xiaowei Zhuang

Nature Communicationsno. 1 (2024): 1-7

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Somatic Cancer Driver Mutations Are Enriched and Associated with Inflammatory States in Alzheimer’s Disease Microglia

bioRxiv the preprint server for biology (2024)

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