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Our research is focused on the theroretical description of regulatory biological networks and their handling with computational tools.
Signal transduction processes and one of their major targets, the control of gene expression by transcriptional regulation, play a central role in nearly all cellular events such as cell cycle reglation, differentation, and response to any kind of environmental impact. We develop data models that represent eukaryotic promoter structures, the features of the transcriptional regulators (transcription factors), and the signaling pathways that influence their activities. We develop databases, populate them with the required information, formalize the representation of the objects in the databases and their relations by ontologies, and try to develop algorithms for the characterization of known regulatory components (e.g., genetic elements, regulatory molecules or pathways) and their identification in as yet uncharacterized systems. Modeling and simulation efforts will be extended onto the effects of pathological aberrations caused by mutations in regulatory components.
Signal transduction processes and one of their major targets, the control of gene expression by transcriptional regulation, play a central role in nearly all cellular events such as cell cycle reglation, differentation, and response to any kind of environmental impact. We develop data models that represent eukaryotic promoter structures, the features of the transcriptional regulators (transcription factors), and the signaling pathways that influence their activities. We develop databases, populate them with the required information, formalize the representation of the objects in the databases and their relations by ontologies, and try to develop algorithms for the characterization of known regulatory components (e.g., genetic elements, regulatory molecules or pathways) and their identification in as yet uncharacterized systems. Modeling and simulation efforts will be extended onto the effects of pathological aberrations caused by mutations in regulatory components.
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论文共 278 篇作者统计合作学者相似作者
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crossref(2022)
Kanix Wang,Robert Stevens, Halima Alachram,Yu Li, Larisa Soldatova,Ross King, Sophia Ananiadou, Annika M. Schoene, Maolin Li,Fenia Christopoulou, José Luis Ambite, Joel Matthew,
user-5d4bc4a8530c70a9b361c870(2021)
D.E. Stelmashenko, F.A. Kolpakov, I.S. Evshin, N.V. Mandrik, A.S. Ryabova, S.S. Pintus, I.N. Kiselev, R.N. Sharipov, P. Stegmaier, J. Koschmann, O.V. Kel-Margoulis,M. Krull,
Laboratory and productionpp.76-86, (2019)
Alexander Kel,Ulyana Boyarskikh,Philip Stegmaier, Leonid S Leskov, Andrey V Sokolov,Ivan Yevshin,Nikita Mandrik,Daria Stelmashenko,Jeannette Koschmann,Olga Kel-Margoulis,Mathias Krull,Anna Martínez Cardús,
BMC Bioinformatics, 2019, vol. 20, num. Suppl 4, p. 119 (2019)
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