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Dr Frohlich was an outstanding researcher, successfully bridging the complexity of laboratory research with the delivery of patient care. As an eminent clinician-scientist, Edward D. Frohlich contributed to our understanding of the consequences of blood pressure elevation on cardiac function and systemic hemodynamics. His contributions to medicine are documented in over 1100 papers (516 original articles listed in PubMed), chapters, editorials and close to 50 books. Ed’s first publication coauthored with Edward Freis, MD, the award-winning medical researcher, was the first publication detailing the changes in cardiac output after treatment with chlorothiazide.3 As recounted elsewhere,1 Frohlich’s fellowship with Freis defined his future investigative career in cardiovascular medicine and in hypertension. During the ensuing years, Dr Frohlich spearheaded new knowledge on the hemodynamic mechanisms of antihypertensive drugs including thiazide diuretics and β-adrenolytic agents. In his exemplary ability to merge knowledge of the clinical and basic science of hypertension, Frohlich was the first to document abnormalities of the ECG P wave in hypertensive patients correlating it with left ventricular involvement.4 Further contributions included scholar activities leading to a better understanding of intracellular expression of local tissue renin angiotensin systems in the heart.5,6 This work was thematically intertwined with his long-term contributions to unravel the mechanisms by which heart function and structure are affected by the development of hypertension.
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Journal of Hypertensionno. 2 (2015): 412-420
Chestno. 5 (2015): 592-595
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